Evidence map›Paper›PMID 28066389›Full record

ArticleFrontiers in microbiology2016

Harnessing Bacterial Signals for Suppression of Biofilm Formation in the Nosocomial Fungal Pathogen

F Jerry Reen, John P Phelan, David F Woods, Rachel Shanahan, Rafael Cano, Sarah Clarke, Gerard P McGlacken, Fergal O'Gara

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Structural modification of theMicrobiology (Reading, England) · 2023
    Article
  7. Article
  8. Co-Operative Biofilm Interactions betweenJournal of fungi (Basel, Switzerland) · 2022
    Article
  9. Article
  10. Action of Extracellular Proteases ofLife (Basel, Switzerland) · 2021
    Article
  11. Review
  12. Review
  13. Article
  14. Coinfection withEuropean respiratory review : an official journal of the European Respiratory Society · 2020
    Review
  15. Review of PotentialJournal of fungi (Basel, Switzerland) · 2020
    Review
  16. Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019
    Review
  17. Interactions betweenJournal of fungi (Basel, Switzerland) · 2019
    Review
  18. Interaction betweenPeerJ · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

F Jerry ReenBIOMERIT Research Centre, School of Microbiology, University College Cork - National University of Ireland Cork, Ireland.
John P PhelanBIOMERIT Research Centre, School of Microbiology, University College Cork - National University of Ireland Cork, Ireland.
David F WoodsBIOMERIT Research Centre, School of Microbiology, University College Cork - National University of Ireland Cork, Ireland.
Rachel ShanahanDepartment of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork - National University of Ireland Cork, Ireland.
Rafael CanoDepartment of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork - National University of Ireland Cork, Ireland.
Sarah ClarkeDepartment of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork - National University of Ireland Cork, Ireland.
Gerard P McGlackenDepartment of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork - National University of Ireland Cork, Ireland.
Fergal O'GaraBIOMERIT Research Centre, School of Microbiology, University College Cork - National University of IrelandCork, Ireland; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, PerthWA, Australia.
National University of Ireland · IEUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Faced with the continued emergence of antibiotic resistance to all known classes of antibiotics, a paradigm shift in approaches toward antifungal therapeutics is required. Well characterized in a broad spectrum of bacterial and fungal pathogens, biofilms are a key factor in limiting the effectiveness of conventional antibiotics. Therefore, therapeutics such as small molecules that prevent or disrupt biofilm formation would render pathogens susceptible to clearance by existing drugs. This is the first report describing the effect of the

Indexed as

alkylhydroxyquinolone (AHQ)Aspergillus fumigatusbiofilmHHQinterkingdom interactionsPQSPseudomonas aeruginosa

Identifiers

PMID28066389
PMCPMC5177741
OpenAlexW2565310393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.