Evidence map›Paper›PMID 28066267›Full record

ArticleFrontiers in physiology2016

FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise.

Andrew A Gibb, Lindsey A McNally, Daniel W Riggs, Daniel J Conklin, Aruni Bhatnagar, Bradford G Hill

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Exercise regulates cardiac metabolism: Sex does matter.Journal of sport and health science · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Guidelines for animal exercise and training protocols for cardiovascular studies.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andrew A GibbDepartment of Medicine, Institute of Molecular Cardiology, University of LouisvilleLouisville, KY, USA; Diabetes and Obesity Center, University of LouisvilleLouisville, KY, USA; Department of Physiology, University of LouisvilleLouisville, KY, USA.
Lindsey A McNallyDepartment of Medicine, Institute of Molecular Cardiology, University of LouisvilleLouisville, KY, USA; Diabetes and Obesity Center, University of LouisvilleLouisville, KY, USA.
Daniel W RiggsDepartment of Medicine, Institute of Molecular Cardiology, University of LouisvilleLouisville, KY, USA; Diabetes and Obesity Center, University of LouisvilleLouisville, KY, USA.
Daniel J ConklinDepartment of Medicine, Institute of Molecular Cardiology, University of LouisvilleLouisville, KY, USA; Diabetes and Obesity Center, University of LouisvilleLouisville, KY, USA.
Aruni BhatnagarDepartment of Medicine, Institute of Molecular Cardiology, University of LouisvilleLouisville, KY, USA; Diabetes and Obesity Center, University of LouisvilleLouisville, KY, USA; Department of Physiology, University of LouisvilleLouisville, KY, USA; Department of Biochemistry and Molecular Genetics, University of LouisvilleLouisville, KY, USA.
Bradford G HillDepartment of Medicine, Institute of Molecular Cardiology, University of LouisvilleLouisville, KY, USA; Diabetes and Obesity Center, University of LouisvilleLouisville, KY, USA; Department of Physiology, University of LouisvilleLouisville, KY, USA; Department of Biochemistry and Molecular Genetics, University of LouisvilleLouisville, KY, USA.
University of Louisville · US

Funding

Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI DEFILIPPIS, ANDREW · 2012 to 2017
$13.8M
TOXICITY OF 4-HYDROXYALKENALS IN HEARTR01HL055477 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BHATNAGAR, ARUNI · 1997 to 2015
$4.4M
Metabolic optimization of cell therapyR01HL130174 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2016 to 2020
$1.9M
American Heart Association-American Stroke Association 16PRE31010022NHLBI NIH HHS R01 HL055477NHLBI NIH HHS R01 HL130174NIGMS NIH HHS P20 GM103492
6 · The paper itself

Abstract

Mice are commonly used to examine the mechanisms by which exercise improves cardiometabolic health; however, exercise compliance and adaptations are often strain-dependent or are variable due to inconsistency in exercise training protocols. In this study, we examined nocturnal/diurnal behavior, treadmill exercise compliance, and systemic as well as cardiac-specific exercise adaptations in two commonly used mouse strains, C57BL/6J, and FVB/NJ mice. Metabolic cage analysis indicated a strong nocturnal nature of C57BL/6J mice, whereas FVB/NJ mice showed no circadian element to activity, food or water intake, VO

Indexed as

cardiac hypertrophycircadiancomplianceexercisemetabolismmitochondriamouse strainphysical activity

Identifiers

PMID28066267
PMCPMC5174104
OpenAlexW2579484052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.