ArticleFrontiers in neural circuits2016
The ON Crossover Circuitry Shapes Spatiotemporal Profile in the Center and Surround of Mouse OFF Retinal Ganglion Cells.
Article in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina.Nature communications · 2025Article
- Modulation of narrow-field amacrine cells on light-evoked spike responses and receptive fields of retinal ganglion cells.Vision research · 2023Article
- Light responses and amacrine cell modulation of morphologically-identified retinal ganglion cells in the mouse retina.Vision research · 2023Article
- Abnormal perception of pattern-induced flicker colors in subjects with glaucoma.Journal of vision · 2022Article
- Single transient intraocular pressure elevations cause prolonged retinal ganglion cell dysfunction and retinal capillary abnormalities in mice.Experimental eye research · 2020Article
- Intraocular Pressure Elevation Compromises Retinal Ganglion Cell Light Adaptation.Investigative ophthalmology & visual science · 2020Article
- New Features of Receptive Fields in Mouse Retina through Spike-triggered Covariance.Experimental neurobiology · 2020Article
- Genetic dissection of rod and cone pathways mediating light responses and receptive fields of ganglion cells in the mouse retina.Vision research · 2020Article
- Mild Intraocular Pressure Elevation in Mice Reveals Distinct Retinal Ganglion Cell Functional Thresholds and Pressure-Dependent Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Elevated IOP alters the space-time profiles in the center and surround of both ON and OFF RGCs in mouse.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
4 authors.
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Abstract
Retinal ganglion cells (RGCs) are often grouped based on their functional properties. Many of these functional properties, such as receptive field (RF) size, are driven by specific retinal circuits. In this report, we determined the role of the ON bipolar cell (BC) mediated crossover circuitry in shaping the center and surround of OFF RGCs. We recorded from a large population of mouse RGCs using a multielectrode array (MEA) while pharmacologically removing the ON BC-mediated crossover circuit. OFF sustained and transient responses to whole field stimuli are lost under scotopic conditions, but maintained under photopic conditions. Though photopic light responses were grossly maintained, we found that photopic light response properties were altered. Using linear RF mapping, we found a significant reduction in the antagonistic surround and a decrease in size of the RF center. Using a novel approach to separate the distinct temporal filters present in the RF center, we see that the crossover pathway contributes specifically to the sluggish antagonistic filter in the center. These results provide new insight into the role of crossover pathways in driving RGCs and also demonstrate that the distinct inputs driving the RF center can be isolated and assayed by RGC activity.
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