ReviewFrontiers in neural circuits2016
Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia.
Review in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Altered wakeful theta activity characterizes levodopa-induced dyskinesia in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Transcranial Magnetic Stimulation in Parkinson's Disease and Parkinsonian Syndromes: A Narrative Expert Review.Life (Basel, Switzerland) · 2026Review
- Stigmasterol Alleviates Levodopa-Induced Dyskinesia in 6-OHDA-Induced Parkinsonian Rats.Neurochemical research · 2025Article
- Neuroinflammation and Dyskinesia: A Possible Causative Relationship?Brain sciences · 2024Review
- Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor.Nature communications · 2023Article
- Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation.Frontiers in immunology · 2023Review
- Contracted thalamic shape is associated with early development of levodopa-induced dyskinesia in Parkinson's disease.Scientific reports · 2022Article
- Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats.Neuroscience bulletin · 2021Article
- ATP Signaling Controlling Dyskinesia Through P2X7 Receptors.Frontiers in molecular neuroscience · 2020Article
- Levodopa/Benserazide PLGA Microsphere Prevents L-Dopa-Induced DyskinesiaFrontiers in pharmacology · 2019Article
- Synaptic plasticity and levodopa-induced dyskinesia: electrophysiological and structural abnormalities.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats.Experimental brain research · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of L-DOPA-induced dyskinesia (LID) in patients with Parkinson disease (PD) could be due to maladaptive plasticity of corticostriatal synapses in response to L-DOPA treatment. A series of recent studies has revealed that LID is associated with marked morphological plasticity of striatal dendritic spines, particularly cell type-specific structural plasticity of medium spiny neurons (MSNs) in the striatum. In addition, evidence demonstrating the occurrence of plastic adaptations, including aberrant morphological and functional features, in multiple components of cortico-basal ganglionic circuitry, such as primary motor cortex (M1) and basal ganglia (BG) output nuclei. These adaptations have been implicated in the pathophysiology of LID. Here, we briefly review recent studies that have addressed maladaptive plastic changes within the cortico-BG loop in dyskinetic animal models of PD and patients with PD.
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