Evidence map›Paper›PMID 28066102›Full record

Trial reportIndian journal of pharmacology

Randomized, double-blind, comparative study of oral metronidazole and tinidazole in treatment of bacterial vaginosis.

Indu M Raja, Asha Basavareddy, Deepali Mukherjee, Bikash Ranjan Meher

Open access · greenAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Indu M RajaDepartment of Pharmacology, Sri Venkateshwaraa Medical College, Puducherry, India.
Asha BasavareddyDepartment of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India.
Deepali MukherjeeDepartment of Pharmacology, Sri Venkateshwaraa Medical College, Puducherry, India.
Bikash Ranjan MeherDepartment of Pharmacology, All Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Sri Venkateshwaraa Medical College Hospital and Research Centre · INAll India Institute of Medical Sciences Bhubaneswar · INSri Devaraj Urs Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the efficacy and tolerability of oral metronidazole and tinidazole in patients with bacterial vaginosis (BV) using Amsel's criteria. PATIENTS AND

methodsThis was a randomized double-blind study, conducted by the Departments of Pharmacology and Gynecology of a tertiary care teaching hospital. Patients diagnosed with BV received either tablet metronidazole 500 mg twice daily for 5 days or tablet tinidazole 500 mg once daily + one placebo for 5 days and instructed to come for follow-up at the 1

resultsA total 120 women were enrolled in the study, of which 114 completed the study. The treatment arms were comparable. The cure rate with low-dose tinidazole was significantly more compared to metronidazole at 4

conclusionTinidazole at lower dose offers a better efficacy than metronidazole in long-term cure rates and in preventing relapses with better side effect profile.

Indexed as

Administration, OralAdolescentAdultAnti-Infective AgentsDouble-Blind MethodFemaleFollow-Up StudiesHumansMetronidazoleMiddle AgedTinidazoleTreatment OutcomeVaginosis, BacterialYoung AdultAnti-Infective AgentsMetronidazoleTinidazoleBacterial vaginosiscure ratemetronidazoletinidazoletolerability

Identifiers

PMID28066102
PMCPMC5155465
OpenAlexW2558407282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.