ArticleEuropean heart journal2017
Increasing sex differences in the use of cardiac resynchronization therapy with or without implantable cardioverter-defibrillator.
Article in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Social Determinants of Health-Related Outcomes in an Intervention Following Initial Implantable Cardioverter-Defibrillator Implantation.Journal of the American Heart Association · 2025Trial
- Gender- and sex-dependent variations in heart failure and cardiomyopathies: a review of the literature.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Heart Failure in Lebanon: A Glimpse into the Reality of Growing Burden.Diagnostics (Basel, Switzerland) · 2025Article
- Integrated Proteomics and Metabolomics Analyses Reveal Molecular Mechanism of Cardiac Resynchronization Therapy Against Cardiac Fibrosis and Ventricular Arrhythmias.Cardiovascular toxicology · 2025Article
- Sex-related similarities and differences in responses to heart failure therapies.Nature reviews. Cardiology · 2024Review
- Trends in cardiac implantable electronic device utilization in adults with congenital heart disease: a US nationwide analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Implantable cardioverter defibrillator and cardiac resynchronization treatment in people with type 2 diabetes: a comparison with age- and sex matched controls from the general population.Cardiovascular diabetology · 2024Article
- Prognosis of CRT-treated and CRT-untreated unselected population with LBBB in Stockholm County.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Remote Patient Monitoring for Patients with Heart Failure: Sex- and Race-based Disparities and Opportunities.Cardiac failure review · 2023Review
- Interamerican Society of Cardiology (CIFACAH - ELECTROSIAC)/Latin American Heart Rhythm Society (LAHRS): multidisciplinary review on the appropriate use of cardiac resynchronization therapy in heart failure.Archivos de cardiologia de Mexico · 2023Article
- Sex-Specific Differences in Ventricular Remodeling and Response After Cardiac Resynchronization Therapy.The American journal of cardiology · 2022Article
- Review
- Heart Failure Subtypes and Cardiomyopathies in Women.Circulation research · 2022Article
- Sex Differences and Temporal Trends in Hospitalization for Catheter Ablation of Nonvalvular Atrial Fibrillation: A Single-Center Experience for 15 Years.Journal of interventional cardiology · 2022Article
- Variation in regional implantation patterns of cardiac implantable electronic device in Switzerland.PloS one · 2022Article
- Sex differences in CRT device implantation rates, efficacy, and complications following implantation: protocol for a systematic review and meta-analysis of cohort studies.Systematic reviews · 2021Article
- Racial/Ethnic and Gender Disparities in Heart Failure with Reduced Ejection Fraction.Current heart failure reports · 2021Review
- Sex and Heart Failure Treatment Prescription and Adherence.Frontiers in cardiovascular medicine · 2021Review
- Sex-Specific Patterns of Mortality Predictors Among Patients Undergoing Cardiac Resynchronization Therapy: A Machine Learning Approach.Frontiers in cardiovascular medicine · 2021Article
- Contemporary use of devices in chronic heart failure in the Netherlands.ESC heart failure · 2020Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsPrevious studies have identified sex disparities in the use of cardiac resynchronization therapy (CRT) and implantable cardioverter defibrillators (ICD), although the basis of underutilization in women remains poorly understood. The aim of this study was to assess sex differences in patterns of CRT use with our without ICD. METHODS AND
resultsIn this cross-sectional study using the National Inpatient Sample database we identified 311 009 patients undergoing CRT implantation in the United States between 2006 and 2012. Demographic and clinical characteristics were compared between men and women undergoing CRT implantation, with special attention to clinical predictors of left ventricular reverse remodelling (CRT response, score range: 0-4) and reduced ICD efficacy (score range: 0-7). When compared to men, women undergoing CRT implantation were significantly more likely to have ≥ 3 predictors of CRT response (47.3 vs. 33.2%, P < 0.001) and less likely to have ≥3 predictors of reduced ICD efficacy (27.0 vs. 37.3%, P < 0.001). Despite this, men were significantly more likely to undergo CRT with ICD (CRT-D) as the type of CRT (88.6 vs. 80.1% of all CRT implants). Compared to those with the greatest likelihood of CRT response (score ≥ 3), those with the least likelihood of CRT response had a significant decreased odds of CRT-D implant (adj odds ratio 0.27 [0.24-0.31], P < 0.001), with a greater decreased odds in women compared to men (P, for sex interaction <0.001). The difference in the % of CRT-D implant in men vs. women increased over the study period (P, sex Δ time trend = 0.012).
conclusionIn this large, contemporary cohort, sex differences in CRT-D implantation were inversely related to predicted CRT efficacy and have increased over time. Future efforts to narrow the gap in CRT-D implantation in men and women may help better align device selection with those most likely to benefit.
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Registered trials
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