Evidence map›Paper›PMID 28065857›Full record

ReviewPharmacological research2017

Downstream Regulatory Element Antagonist Modulator (DREAM), a target for anti-thrombotic agents.

Jaehyung Cho

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacological research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. KCells · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jaehyung ChoDepartment of Pharmacology, University of Illinois-Chicago College of Medicine, USA. Electronic address: thromres@uic.edu.
University of Illinois Chicago · US

Funding

Thiol isomerases in neutrophil recruitment and thromboinflammatory diseaseR01HL130028 · NHLBI · WASHINGTON UNIVERSITY · PI CHO, JAEHYUNG · 2016 to 2024
$3.6M
Protein disulfide isomerase in neutrophil recruitment and vascular inflammationR01HL109439 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHO, JAEHYUNG · 2011 to 2015
$2.0M
NHLBI NIH HHS R01 HL109439NHLBI NIH HHS R01 HL130028
6 · The paper itself

Abstract

Circulating platelets participate in the process of numerous diseases including thrombosis, inflammation, and cancer. Thus, it is of great importance to understand the underlying mechanisms mediating platelet activation under disease conditions. Emerging evidence indicates that despite the lack of a nucleus, platelets possess molecules that are involved in gene transcription in nucleated cells. This review will summarize downstream regulatory element antagonist modulator (DREAM), a transcriptional repressor, and highlight recent findings suggesting its novel non-transcriptional role in hemostasis and thrombosis.

Indexed as

AnimalsBlood PlateletsCell NucleusFibrinolytic AgentsHumansKv Channel-Interacting ProteinsThrombosisFibrinolytic AgentsKv Channel-Interacting ProteinsDREAMPlatelet activationThrombosis and hemostasis

Identifiers

PMID28065857
PMCPMC5316308
OpenAlexW2568033437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.