ArticleClinical colorectal cancer2017
Racial Differences in Stage IV Colorectal Cancer Survival in Younger and Older Patients.
Article in Clinical colorectal cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Artificial Intelligence-Guided Analysis of WNT Pathway Alterations: Associations with Genomic Burden and Survival Across African American and Non-Hispanic White Populations, Age Groups, and FOLFOX Treatment in Colorectal Cancer.International journal of molecular sciences · 2026Article
- Differences in T-cell Densities and Neighborhood Patterns in Human Colorectal Adenomas and Sessile Serrated Lesions.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Demonstrating trends for early colorectal cancer incidence: a retrospective analysis of patients in Northwest Ohio.Frontiers in oncology · 2026Article
- Risk prediction of advanced colorectal neoplasia varies by race and neighbourhood socioeconomic status.Family medicine and community health · 2024Article
- Receipt of Targeted Therapy and Survival Outcomes in Patients With Metastatic Colorectal Cancer.JAMA network open · 2023Article
- Overall Survival Differences in Young Black Colorectal Cancer Patients: a Report from the National Cancer Database.Journal of Cancer · 2023Article
- Evaluation of thromboembolic event, basic coagulation parameters, and associated factors in patients with colorectal cancer: a multicenter study.Frontiers in oncology · 2023Article
- Young-Onset Colon Cancer: A Case Report.Cureus · 2022Article
- Understanding geographic and racial/ethnic disparities in mortality from four major cancers in the state of Georgia: a spatial epidemiologic analysis, 1999-2019.Scientific reports · 2022Article
- Genetic Evaluation for Hereditary Cancer Syndromes Among African Americans: A Critical Review.The oncologist · 2022Review
- The association of health insurance and race with treatment and survival in patients with metastatic colorectal cancer.PloS one · 2022Article
- Incidence of Mortality and Associated Factors Among Colorectal Cancer Patients at Oncology Units of Northwest Ethiopia: A Retrospective Cohort Study.Cancer management and research · 2022Article
- Young-onset colorectal cancer: A review.World journal of gastrointestinal oncology · 2021Review
- Differential immune signatures in the tumor microenvironment are associated with colon cancer racial disparities.Cancer medicine · 2021Article
- Preinvasive Colorectal Lesions of African Americans Display an Immunosuppressive Signature Compared to Caucasian Americans.Frontiers in oncology · 2021Article
- Patterns of racial/ethnic disparities in baseline health-related quality of life and relationship with overall survival in patients with colorectal cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Platelet and hemoglobin count at diagnosis are associated with survival in African American and Caucasian patients with colorectal cancer.Cancer epidemiology · 2020Article
- Racial Disparities in Incidence of Young-Onset Colorectal Cancer and Patient Survival.Gastroenterology · 2019Article
- Tumor-Infiltrating Lymphocytes and Colorectal Cancer Survival in African American and Caucasian Patients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan.BMC cancer · 2018Article
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Authors and funding
10 authors.
Funding
Abstract
introductionAfrican Americans (AAs) compared with European Americans (EAs) have poorer stage-specific survival from colorectal cancer (CRC). Recent reports have indicated that the racial difference in survival has worsened over time, especially among younger patients. To better characterize this association, we used population-based Surveillance, Epidemiology, and End Results registry data to evaluate the effect of race on stage IV CRC survival in patients aged < 50 and ≥ 50 years. PATIENTS AND
methodsThe population included 16,782 patients diagnosed with stage IV colon and rectal adenocarcinoma from January 1, 2004 and December 31, 2011. Cox proportional hazards regression was used to evaluate the association between race and other prognostic factors and the risk of death in each age group.
resultsYounger AAs compared with EAs had a greater prevalence of proximal CRC at diagnosis, a factor associated with a significantly greater risk of death in both races. Among patients < 50 years old, AAs had a greater risk of death compared with EAs (hazard ratio, 1.35; 95% confidence interval, 1.20-1.51), which was attenuated in patients ≥ 50 years of age (hazard ratio, 1.10; 95% confidence interval, 1.04-1.16); P for interaction = .01.
conclusionThe results revealed poor overall survival for AAs compared with EAs, especially for those < 50 years of age. The greater prevalence of proximal CRC at diagnosis among younger AAs (vs. EAs) might contribute to the racial difference in survival. Future studies are needed to understand how the colonic location affects the efficacy of treatment regimens.
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