ReviewAutonomic neuroscience : basic & clinical2018
Challenging cardiac function post-spinal cord injury with dobutamine.
Review in Autonomic neuroscience : basic & clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Acute cardio-centric haemodynamic management preserves chronic cardiovascular function in pigs with high-thoracic spinal cord injury.The Journal of physiology · 2026Article
- "Chronic Cervical Midline Contusion in Rats Disrupts Aerobic, Muscular, and Cardiovascular Function".bioRxiv : the preprint server for biology · 2025Article
- Effects of C2 hemisection on respiratory and cardiovascular functions in rats.Neural regeneration research · 2023Article
- The susceptibility of cardiac arrhythmias after spinal cord crush injury in rats.Experimental neurology · 2022Article
- Trends in the presentation and management of traumatic spinal cord lesions above T6: 20-Year experience in a tertiary-level hospital in Spain.The journal of spinal cord medicine · 2022Observational
- Impact of Enteral Albuterol on Bradycardic Events After Acute Cervical Spinal Cord Injury.Neurocritical care · 2022Article
- Article
- Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury.Nature communications · 2020Article
- Direct comparison of cervical and high thoracic spinal cord injury reveals distinct autonomic and cardiovascular consequences.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Chronic, complete cervicalJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Temporal analysis of cardiovascular control and function following incomplete T3 and T10 spinal cord injury in rodents.Physiological reports · 2018Article
- Spinal Cord Injury Causes Systolic Dysfunction and Cardiomyocyte Atrophy.Journal of neurotrauma · 2018Article
- A comparison of passive hindlimb cycling and active upper-limb exercise provides new insights into systolic dysfunction after spinal cord injury.American journal of physiology. Heart and circulatory physiology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
There is general consensus that spinal cord injuries (SCI) above T6 result in altered sympathetic control of the heart, which negatively influences cardiac structure and function. To by-pass disrupted circuitry and investigate cardiac responses under enhanced sympathetic activity we utilized dobutamine (DOB) stress echocardiography. Animals were divided into a T2, 25g-cm contusive SCI (SCI) or an uninjured control (CON) group. Echocardiography was performed pre-SCI and at 1, 2 and 6weeks post-SCI. Increasing doses of DOB (5, 10 & 20μg/min/kg) were infused intravenously pre-SCI and at 1 and 6weeks post-SCI. Parasternal-short axis images were used to compare group differences in systolic function and track changes in response to SCI and DOB over time. One week post-SCI, stroke volume (SV), end diastolic volume (EDV), cardiac output (CO) and ejection fraction (EF) were all reduced compared to CON and these deficits persisted to 6weeks. We also found an increase in collagen deposition at 6weeks post SCI. Pre-SCI, DOB elicited a decrease in EDV and increases in CO, EF and HR but not SV. At 6weeks following SCI, in addition to increases in CO, EF and HR, DOB also induced increases in SV. This is the first report, to our knowledge, of DOB responses in a contusive SCI model with persistent cardiac impairments. The return of CO to pre-SCI levels and the substantial increase in SV at low DOB dosages shows that impaired descending control of the heart is directly contributing to reduced resting SV after SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.