Evidence map›Paper›PMID 28065412›Full record

ArticleCell2017

Quantitative Predictions Orchestrate Visual Signaling in Drosophila.

Anmo J Kim, Lisa M Fenk, Cheng Lyu, Gaby Maimon

Open access · greenAbstract read
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 151 citations in OpenAlex.

  1. Article
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  6. bioRxiv : the preprint server for biology · 2025
    Article
  7. How tp1, an indirect wing steering muscle, stabilizesbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
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  10. On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025
    Review
  11. Article
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  15. Article
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  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anmo J KimLaboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA.
Lisa M FenkLaboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA.
Cheng LyuLaboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA.
Gaby MaimonLaboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA. Electronic address: maimon@rockefeller.edu.
Rockefeller University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK · 2014 to 2026
$13.5M
Linking genes to higher brain function by way of cellular electrophysiologyDP2DA035148 · NIDA · ROCKEFELLER UNIVERSITY · PI MAIMON, GABY · 2012 to 2017
$3.1M
NIDA NIH HHS DP2 DA035148NIH HHS P40 OD018537
6 · The paper itself

Abstract

Vision influences behavior, but ongoing behavior also modulates vision in animals ranging from insects to primates. The function and biophysical mechanisms of most such modulations remain unresolved. Here, we combine behavioral genetics, electrophysiology, and high-speed videography to advance a function for behavioral modulations of visual processing in Drosophila. We argue that a set of motion-sensitive visual neurons regulate gaze-stabilizing head movements. We describe how, during flight turns, Drosophila perform a set of head movements that require silencing their gaze-stability reflexes along the primary rotation axis of the turn. Consistent with this behavioral requirement, we find pervasive motor-related inputs to the visual neurons, which quantitatively silence their predicted visual responses to rotations around the relevant axis while preserving sensitivity around other axes. This work proposes a function for a behavioral modulation of visual processing and illustrates how the brain can remove one sensory signal from a circuit carrying multiple related signals.

Indexed as

Visual PathwaysAnimalsDrosophila melanogasterFlight, AnimalHead MovementsNeuronsOptic FlowPatch-Clamp TechniquesPotassium Channels, Inwardly RectifyingKir2.1 channelPotassium Channels, Inwardly Rectifyingaction initiationcorollary dischargeDrosophilaefference copyelectrophysiologyeye movementsneural circuitspatch-clampvisionvisuomotor processing

Identifiers

PMID28065412
PMCPMC6320683
OpenAlexW2570782440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.