Evidence map›Paper›PMID 28065359›Full record

ReviewThe journal of sexual medicine2017

Role of Nanotechnology in Erectile Dysfunction Treatment.

Alice Y Wang, Carol A Podlasek

Open access · greenAbstract readReview
In one paragraph

Review in The journal of sexual medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Lipid-based nanoparticles in the treatment of erectile dysfunction.International journal of impotence research · 2020
    Review
  10. Development of nanotechnology in andrology.Translational andrology and urology · 2020
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alice Y WangDepartment of Urology, University of Illinois at Chicago, Chicago, IL, USA.
Carol A PodlasekDepartments of Urology, Physiology, and Bioengineering, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: cap325@uic.edu.
University of Illinois Chicago · US

Funding

3-Way Approach for ED PreventionR01DK101536 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Carol Ann Podlasek · 2014 to 2026
$5.9M
NIDDK NIH HHS R01 DK101536
6 · The paper itself

Abstract

introductionThe biological importance of nanotechnology-based delivery vehicles for in vivo tissue regeneration is gaining acceptance by the medical community; however, its relevance and incorporation into the treatment of sexual dysfunction are evolving and have not been well evaluated.

aimTo provide scientific evidence examining the use of state-of-the-art nanotechnology-based delivery methodology in the treatment of erectile dysfunction (ED) in animal models and in patients.

methodsThis review assessed the current basic science literature examining the role of nanotechnology-based delivery vehicles in the development of potential ED therapies.

resultsThere are four primary areas where nanotechnology has been applied for ED treatment: (i) topical delivery of drugs for on-demand erectile function, (ii) injectable gels into the penis to prevent morphologic changes after prostatectomy, (iii) hydrogels to promote cavernous nerve regeneration or neuroprotection, and (iv) encapsulation of drugs to increase erectile function (primarily of phosphodiesterase type 5 inhibitors).

conclusionBasic science studies provide evidence for a significant and evolving role for nanotechnology in the development of therapies for ED and suggest that properly administered nano-based therapies might be advantageous for treating male sexual dysfunction.

Indexed as

NanotechnologyAnimalsDisease Models, AnimalErectile DysfunctionHumansMaleNerve RegenerationPenile ErectionPhosphodiesterase 5 InhibitorsProstatectomyPhosphodiesterase 5 InhibitorsCavernous NerveErectile DysfunctionHydrogelNanotechnologyPenis

Identifiers

PMID28065359
PMCPMC5268133
OpenAlexW2568212947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.