GuidelineThe Journal of allergy and clinical immunology2017
Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel.
Guideline in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 188 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants at High Risk of Tree Nut Allergy: The TreEat Study: a Randomised, Open-label Controlled Trial
Development of Peanut, Sesame, and Tree Nut Allergy in Polish Children at High Risk of Food Allergy
Early Introduction and Sustained Ingestion (EISI) Using Two Educational Opportunities - A Pilot Study
Who cites it
188 citing papers in PubMed, 3 syntheses or guidelines pooled it, 486 citations in OpenAlex.
- Dietary Management of IgE-Mediated and Non-IgE-Mediated Food Allergies: A Systematic Review of Current Evidence and Clinical Implications.Nutrients · 2026Pooled it
- Implementation of the Addendum Guidelines for Peanut Allergy Prevention by US allergists, a survey conducted by the NIAID, in collaboration with the AAAAI.The Journal of allergy and clinical immunology · 2020Guideline
- Guideline
- Dosing Reactions and Missed Doses Affect Peanut Oral Immunotherapy Outcomes.The journal of allergy and clinical immunology. In practice · 2026Trial
- Assessing pediatric clinician adherence to the guidelines for prevention of peanut allergy: a natural language processing study.BMC medical informatics and decision making · 2025Trial
- Pediatric Clinician Adherence to Peanut Allergy Prevention Guidelines: A Randomized Trial.Pediatrics · 2025Trial
- Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention.NEJM evidence · 2024Trial
- Feeding Practices and Dietary Diversity in the First Year of Life: PreventADALL, a Scandinavian Randomized Controlled Trial and Birth Cohort Study.The Journal of nutrition · 2023Trial
- Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses.Allergy · 2023Trial
- Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study.Lancet (London, England) · 2022Trial
- HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.The Journal of clinical investigation · 2022Trial
- Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy.The Journal of allergy and clinical immunology · 2019Trial
- Is age a critical factor for the diagnosis of peanut allergy in children?The World Allergy Organization journal · 2026Article
- Review
- Early Peanut Introduction for Allergy Prevention: Evidence and Practical Implementation in Pediatric Practice.Cureus · 2026Review
- Microbial fermentation as a strategy for the abatement of peanut allergens.Applied and environmental microbiology · 2026Review
- Early Allergen Introduction in Delaware: A Model to Address Healthcare Disparities and Population Healthcare Costs.Cureus · 2026Review
- Implementation of early peanut introduction among providers in a southern US state.The journal of allergy and clinical immunology. Global · 2026Article
- Decision Support Tools Strengthen Early Peanut Introduction Practices and Streamline Data Automation.Cureus · 2026Article
- Rising trends in infant ER encounters for food-induced allergic reactions in the era of early allergenic food introduction.The journal of allergy and clinical immunology. Global · 2026Article
128 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
30 authors at 20 institutions in 3 countries.
Funding
Abstract
backgroundFood allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy.
objectivesPrompted by these findings, along with 25 professional organizations, federal agencies, and patient advocacy groups, the National Institute of Allergy and Infectious Diseases facilitated development of addendum guidelines to specifically address the prevention of peanut allergy.
resultsThe addendum provides 3 separate guidelines for infants at various risk levels for the development of peanut allergy and is intended for use by a wide variety of health care providers. Topics addressed include the definition of risk categories, appropriate use of testing (specific IgE measurement, skin prick tests, and oral food challenges), and the timing and approaches for introduction of peanut-containing foods in the health care provider's office or at home. The addendum guidelines provide the background, rationale, and strength of evidence for each recommendation.
conclusionsGuidelines have been developed for early introduction of peanut-containing foods into the diets of infants at various risk levels for peanut allergy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.