Evidence map›Paper›PMID 28065276›Full record

ReviewThe Journal of allergy and clinical immunology2017

Using imaging as a biomarker for asthma.

Abhaya Trivedi, Chase Hall, Eric A Hoffman, Jason C Woods, David S Gierada, Mario Castro

Registry-linked trialAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07602192 (Prospective Multicenter Cohort to Discriminate Asthma Versus Chronic Obstructive Pulmonary Disease and Predict Treatment Response Using Quantitative Chest CT and Multi-Omics), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07602192 recruitingnot on this mapstarted 2025, after this paper: background citation

Prospective Multicenter Cohort to Discriminate Asthma Versus Chronic Obstructive Pulmonary Disease and Predict Treatment Response Using Quantitative Chest CT and Multi-Omics

TypeobservationalSponsorKorea University Guro HospitalRan2025 to 2027Enrolled200ConditionsAsthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Single-Session Bronchial Thermoplasty Guided byAmerican journal of respiratory and critical care medicine · 2020
    Trial
  2. Observational
  3. Observational
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Observational
  12. Review
  13. Article
  14. Article
  15. Airway remodeling in asthma.Annals of translational medicine · 2022
    Article
  16. Review
  17. Observational
  18. The emerging role of quantitative imaging in asthma.The British journal of radiology · 2022
    Article
  19. Article
  20. MMEFInternational journal of physiology, pathophysiology and pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abhaya TrivediDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo.
Chase HallDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo.
Eric A HoffmanDepartment of Biomedical Engineering, Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa.
Jason C WoodsCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
David S GieradaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo.
Mario CastroDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo. Electronic address: castrom@wustl.edu.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1M
Severe Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8M
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated EmphysemaR01HL130883 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2016 to 2020
$3.6M
Airway Remodeling in Severe AsthmaR01HL069149 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2001 to 2005
$2.5M
Pediatric Infectious Diseases and Immunity Training ProgramT32AI106688 · NIAID · WASHINGTON UNIVERSITY · PI Megan Anne Cooper, DAVID HUNSTAD · 2014 to 2026
$1.9M
SEVERE ASTHMA RESEARCH PROGRAM (SARPII) IMAGING CORER01HL091762 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2008 to 2011
$1.6M
NHLBI NIH HHS R01 HL069149NHLBI NIH HHS R01 HL091762NHLBI NIH HHS R01 HL130883NHLBI NIH HHS T32 HL007317NHLBI NIH HHS U10 HL109257NIAID NIH HHS T32 AI106688NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, including severity of disease and pathology, but also provide unique phenotypes. Hyperpolarized

Indexed as

AsthmaBiomarkersHumansLungMagnetic Resonance ImagingPositron-Emission TomographyTomography, X-Ray ComputedBiomarkersbiomarkerchest CTImagingMRIPET

Identifiers

PMID28065276
PMCPMC5224930

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.