Evidence map›Paper›PMID 28065270›Full record

ArticleMethods in enzymology2017

Functional Study of the Vitamin K Cycle Enzymes in Live Cells.

J-K Tie, D W Stafford

Open access · greenAbstract read
In one paragraph

Article in Methods in enzymology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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  19. Determining the necessity of phenyl ring π-character in warfarin.Bioorganic & medicinal chemistry letters · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J-K TieUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: jktie@email.unc.edu.
D W StaffordUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · US

Funding

Characterization of enzymes in the vitamin K cycleR01HL131690 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STAFFORD, DARREL W, TIE, JIANKE · 2016 to 2023
$4.0M
NHLBI NIH HHS R01 HL131690
6 · The paper itself

Abstract

Vitamin K-dependent carboxylation, an essential posttranslational modification catalyzed by gamma-glutamyl carboxylase, is required for the biological functions of proteins that control blood coagulation, vascular calcification, bone metabolism, and other important physiological processes. Concomitant with carboxylation, reduced vitamin K (KH

Indexed as

AnimalsEnzyme AssaysEnzyme-Linked Immunosorbent AssayHumansNAD(P)H Dehydrogenase (Quinone)Protein Processing, Post-TranslationalVitamin KVitamin K 1Vitamin K Epoxide ReductasesNAD(P)H Dehydrogenase (Quinone)Vitamin KVitamin K 1vitamin K1 hydroquinonevitamin K1 oxideVitamin K Epoxide ReductasesCoagulation factorsCRISPR-Cas9Gamma-glutamyl carboxylaseMatrix Gla proteinTALENsVitamin K cycleVitamin K epoxide reductaseWarfarin

Identifiers

PMID28065270
PMCPMC5812275
OpenAlexW2557022739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.