ArticleBMC medicine2017
Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Article in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Plasma-Based Proteomics Profiling of Patients with Hyperthyroidism after Antithyroid Treatment.Molecules (Basel, Switzerland) · 2020Trial
- Thyroid dysfunction and cardiovascular disease.European heart journal · 2026Review
- Differential Expression of Complement Pathway Components in Unexplained Infertility Versus Male Factor Infertility: Insights from an Exploratory Pilot Study.International journal of molecular sciences · 2025Article
- Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization.EBioMedicine · 2024Article
- Optimizing the Dutch newborn screening for congenital hypothyroidism by incorporating amino acids and acylcarnitines in a machine learning-based model.European thyroid journal · 2023Article
- Cerebral Venous Thrombosis during Thyrotoxicosis: Case Report and Literature Update.Journal of personalized medicine · 2023Review
- Thyroid Hormone Abuse Among Elite Athletes.Journal of the Endocrine Society · 2023Article
- Alteration of Serum Proteome in Levo-Thyroxine-Euthyroid Thyroidectomized Patients.Journal of clinical medicine · 2022Article
- Immunometabolic signatures predict recovery from thyrotoxic myopathy in patients with Graves' disease.Journal of cachexia, sarcopenia and muscle · 2022Article
- HBFP: a new repository for human body fluid proteome.Database : the journal of biological databases and curation · 2021Article
- Human body-fluid proteome: quantitative profiling and computational prediction.Briefings in bioinformatics · 2021Review
- A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans.Thyroid : official journal of the American Thyroid Association · 2019Article
- New Interfaces of Thyroid Hormone Actions With Blood Coagulation and Thrombosis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Review
- Article
- Combining micro-RNA and protein sequencing to detect robust biomarkers for Graves' disease and orbitopathy.Scientific reports · 2018Article
- A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.GeroScience · 2018Article
- Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves' Disease.International journal of endocrinology · 2018Article
- Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeterminations of thyrotropin (TSH) and free thyroxine (FT
methodsA sample of 16 healthy young men were treated with levothyroxine for 8 weeks and plasma was sampled before the intake was started as well as at two points during treatment and after its completion, respectively. Mass spectrometry-derived metabolite and protein levels were related to FT
resultsDespite the absence of obvious clinical symptoms, mass spectrometry analyses detected 65 metabolites and 63 proteins exhibiting significant associations with serum FT
conclusionOur results emphasize the power of untargeted OMICs approaches to detect novel pathways of thyroid hormone action. Furthermore, beyond TSH and FT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.