ArticlePharmaceutical biology2017
Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 115 citations in OpenAlex.
- Comprehensive Studies on the Regulation of Type 2 Diabetes by Cucurbitane-Type Triterpenoids inPharmaceuticals (Basel, Switzerland) · 2025Article
- Investigating Ayurvedic Strategies: An In-Depth Examination of Managing Diabetes across Different Types.Current diabetes reviews · 2025Review
- Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review.Nutrients · 2024Review
- Natural Functional Beverages as an Approach to Manage Diabetes.International journal of molecular sciences · 2023Review
- Article
- Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey.Frontiers in endocrinology · 2023Article
- Transcriptome analysis of five different tissues of bitter gourd (Momordica charantia L.) fruit identifies full-length genes involved in seed oil biosynthesis.Scientific reports · 2022Article
- From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts.Nutrients · 2022Review
- Article
- Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review.Frontiers in pharmacology · 2022Review
- D-optimal mixture design optimized solid formulation containing fruits extracts of Momordica charantia and Abelmoschus esculentus.PloS one · 2022Article
- Double emulsion-based mayonnaise encapsulated with bitter gourd extract exhibits improvement in vivo anti-diabetic action in STZ induced rats.3 Biotech · 2021Article
- Trends in diabetes care with special emphasis to medicinal plants: Advancement and treatment.Biocatalysis and agricultural biotechnology · 2021Review
- Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery.Antioxidants (Basel, Switzerland) · 2021Review
- The Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Pharmacokinetic Profile and Oral Bioavailability of Diosgenin, Charantin, and Hydroxychalcone From a Polyherbal Formulation.Frontiers in pharmacology · 2021Article
- Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review.Journal of diabetes and metabolic disorders · 2020Review
- Comparative Study of the Chemical Compositions and Antioxidant Activities of Fresh Juices from Romanian Cucurbitaceae Varieties.Molecules (Basel, Switzerland) · 2020Article
- Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery.Biology · 2020Review
- Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus.Systematic reviews · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextMomordica charantia Linn (Cucurbitaceae) (MC) is used in folk medicine to treat various diseases including diabetes mellitus.
objectiveThis study investigates the antidiabetic activities of Momordica charantia (bitter gourd) on streptozotocin-induced type 2 diabetes mellitus in rats. MATERIALS AND
methodsMale Wister rats were randomly assigned to 4 groups. Group I, Normal control; Group II, STZ diabetic; Group III and IV, Momordica charantia fruit juice was orally administered to diabetic rats (10 mL/kg/day either as prophylaxis for 14 days before induction of diabetes then 21 days treatment, or as treatment given for 21 days after induction of diabetes). The effects of MC juice were studied both in vivo and in vitro by studying the glucose uptake of isolated rat diaphragm muscles in the presence and absence of insulin. Histopathological examination of pancreas was also performed.
resultsThis study showed that MC caused a significant reduction of serum glucose (135.99 ± 6.27 and 149.79 ± 1.90 vs. 253.40* ± 8.18) for prophylaxis and treatment respectively, fructosamine (0.99 ± 0.01 and 1.01 ± 0.04 vs. 3.04 ± 0.07), total cholesterol, triglycerides levels, insulin resistance index (1.13 ± 0.08 and 1.19 ± 0.05 vs. 1.48 ± 1.47) and pancreatic malondialdehyde content (p < 0.05). While it induced a significant increase of serum insulin (3.41 ± 0.08 and 3.28 ± 0.08 vs. 2.39 ± 0.27), HDL-cholesterol, total antioxidant capacity levels, β cell function percent, and pancreatic reduced glutathione (GSH) content (p < 0.05) and improved histopathological changes of the pancreas. It also increased glucose uptake by diaphragms of normal (12.17 ± 0.60 vs. 9.07 ± 0.66) and diabetic rats (8.37 ± 0.28 vs. 4.29 ± 0.51) in the absence and presence of insulin (p < 0.05).
conclusionsMomordica charantia presents excellent antidiabetic and antioxidant activities and thus has great potential as a new source for diabetes treatment whether it is used for prophylaxis or treatment.
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