Evidence map›Paper›PMID 28064406›Full record

ArticleMetabolic brain disease2017

Up-regulation of Vps4A promotes neuronal apoptosis after intracerebral hemorrhage in adult rats.

Jianbing Ren, Debin Yuan, Lili Xie, Xuelei Tao, Chenwei Duan, Yifeng Bao, Yunfeng He, Jianbin Ge, Hongjian Lu

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jianbing RenDepartment of Rehabilitation, the Second People's Hospital of Nantong, Nantong, Jiangsu Province, 226001, China.
Debin YuanJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, Jiangsu Province, 226001, China.
Lili XieJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, Jiangsu Province, 226001, China.
Xuelei TaoDepartment of Rehabilitation, the Second People's Hospital of Nantong, Nantong, Jiangsu Province, 226001, China.
Chenwei DuanDepartment of Rehabilitation, the Second People's Hospital of Nantong, Nantong, Jiangsu Province, 226001, China.
Yifeng BaoJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, Jiangsu Province, 226001, China.
Yunfeng HeJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, Jiangsu Province, 226001, China.
Jianbin GeDepartment of Rehabilitation, the Second People's Hospital of Nantong, Nantong, Jiangsu Province, 226001, China. ntgjb2016@163.com.
Hongjian LuDepartment of Rehabilitation, the Second People's Hospital of Nantong, Nantong, Jiangsu Province, 226001, China. luhongjianlucky@163.com.
Affiliated Hospital of Nantong University · CNSecond People's Hospital of NanTong · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vps4, vacuolar protein sorting 4, belongs to ATPases Associated with diverse cellular Activities (AAA) protein family which is made up of Vps4A and Vps4B. Previous studies demonstrated that Vps4A plays vital roles in diverse aspects such as virus budding, the efficient transport of H-Ras to the PM (plasma membrane) and the involvement in the MVB (multivesiculate bodies) pathway. Interestingly, Vps4A is also expressed in the brain. However, the distribution and function of Vps4A in ICH diseases remain unclear. In this study, we show that Vps4A may be involved in neuronal apoptosis during pathophysiological processes of intracerebral hemorrhage (ICH). Based on the results of Western blot and immunohistochemistry, we found a remarkable up-regulation of Vps4A expression surrounding the hematoma after ICH. Double labeled immunofluorescence showed that Vps4A was co-expressed with NeuN but rarely with astrocytes and microglia. Morever, we detected that neuronal apoptosis marker active caspase-3 had co-localizations with Vps4A. Additionaly, Vps4A knockdown in vitro specifically leads to decreasing neuronal apoptosis coupled with increased Akt phosphorylation. All datas suggested that Vps4A was involved in promoting neuronal apoptosis via inhibiting Akt phosphorylation after ICH.

Indexed as

AnimalsAntigens, NuclearApoptosisATPases Associated with Diverse Cellular ActivitiesBehavior, AnimalCaspase 3Cerebral HemorrhageFemaleGene Knockdown TechniquesMaleNerve Tissue ProteinsOncogene Protein v-aktPhosphorylationPregnancyPrimary Cell CultureRatsAntigens, NuclearATPases Associated with Diverse Cellular ActivitiesCasp3 protein, ratCaspase 3Nerve Tissue ProteinsOncogene Protein v-aktRbfox3 protein, ratVacuolar Proton-Translocating ATPasesVps4A protein, ratApoptosisIntracerebral hemorrhageNeuronVps4A

Identifiers

PMID28064406
OpenAlexW2567893324

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.