Evidence map›Paper›PMID 28064227›Full record

ArticleIn vivo (Athens, Greece)2017

PET Probe-Guided Surgery in Patients with Breast Cancer: Proposal for a Methodological Approach.

Paolo Orsaria, Agostino Chiaravalloti, Alessandro Fiorentini, Chiara Pistolese, Gianluca Vanni, Alessandra Vittoria Granai, Dimitrios Varvaras, Roberta Danieli, Orazio Schillaci, Giuseppe Petrella and 1 more

Registry-linked trialOpen access · diamondAbstract readCase Reports
In one paragraph

Article in In vivo (Athens, Greece), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07331532 (PET Imaging Study of 68Ga-PFA2 Probe for Annexin A2-Positive Tumors), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07331532 recruitingnot on this mapstarted 2025, after this paper: background citation

PET Imaging Study of 68Ga-PFA2 Probe for Annexin A2-Positive Tumors

Typeobservational_patient_registrySponsorPeking University First HospitalRan2025 to 2027Enrolled10ConditionsBreast Neoplasms、Lung Neoplasms、Pancreatic Neoplasms
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Paolo OrsariaDepartment of Surgery, Tor Vergata University Hospital, Rome, Italy orsaria@aol.it.
Agostino ChiaravallotiDepartment of Biomedicine and Prevention, Tor Vergata University Hospital, Rome, Italy.
Alessandro FiorentiniDepartment of Biomedicine and Prevention, Tor Vergata University Hospital, Rome, Italy.
Chiara PistoleseDepartment of Biomedicine and Prevention, Tor Vergata University Hospital, Rome, Italy.
Gianluca VanniDepartment of Surgery, Tor Vergata University Hospital, Rome, Italy.
Alessandra Vittoria GranaiDepartment of Surgery, Tor Vergata University Hospital, Rome, Italy.
Dimitrios VarvarasDepartment of Surgery, Tor Vergata University Hospital, Rome, Italy.
Roberta DanieliDepartment of Biomedicine and Prevention, Tor Vergata University Hospital, Rome, Italy.
Orazio SchillaciDepartment of Biomedicine and Prevention, Tor Vergata University Hospital, Rome, Italy.
Giuseppe PetrellaDepartment of Surgery, Tor Vergata University Hospital, Rome, Italy.
Oreste Claudio BuonomoDepartment of Surgery, Tor Vergata University Hospital, Rome, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough it is valuable for detecting distant metastases, identifying recurrence, and evaluating responses to chemotherapy, the role of PATIENTS AND

methodsThree patients underwent a PET/CT scan immediately prior to surgery following the standard clinical protocol. Intraoperatively, tumors were localized and resected with the assistance of a hand-held gamma probe. PET-guided assessment of the presence or absence of regional nodal spread of malignancy was compared with the reference standard of histopathological examination.

resultsIn all three cases, perioperative

conclusionThis innovative approach demonstrates great promise for providing real-time access to metabolic and morphological tumor information that may lead to an optimal disease-tailored approach. In carefully selected indications, a PET probe can be a useful adjunct in surgical practice, but further trials with a larger number of patients need to be performed to verify these findings.

Indexed as

AgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastFemaleFluorodeoxyglucose F18HumansLymphatic MetastasisMolecular ProbesNeoplasm Recurrence, LocalPilot ProjectsPositron Emission Tomography Computed TomographyPrognosisRadiopharmaceuticalsSurgery, Computer-AssistedTissue DistributionFluorodeoxyglucose F18Molecular ProbesRadiopharmaceuticalsBreast cancernodal stagingpositron-emission tomography (PET) proberadio-guided surgerysentinel node

Identifiers

PMID28064227
PMCPMC5354134
OpenAlexW2575003511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.