Evidence map›Paper›PMID 28064148›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Community Weight Loss to Combat Obesity and Disability in At-Risk Older Adults.

W Jack Rejeski, Walter T Ambrosius, Jonathan H Burdette, Michael P Walkup, Anthony P Marsh

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  8. Application of the DJournal of cachexia, sarcopenia and muscle · 2023
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  15. Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

W Jack RejeskiDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.
Walter T AmbrosiusDepartment of Biostatistical Sciences.
Jonathan H BurdetteDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Michael P WalkupDepartment of Biostatistical Sciences.
Anthony P MarshDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Cooperative Lifestyle Intervention Programs (CLIP-II)R18HL076441 · NHLBI · WAKE FOREST UNIVERSITY · PI MARSH, ANTHONY P, REJESKI, WALTER JOHN · 2012 to 2016
$3.1M
NHLBI NIH HHS R18 HL076441NIA NIH HHS P30 AG021332
6 · The paper itself

Abstract

backgroundAmong older, overweight, and obese adults with either cardiovascular disease or the metabolic syndrome, reduced mobility and loss of leg strength are important risk factors for morbidity, disability, and mortality. It is unclear whether community-based approaches to weight loss may be an effective solution to this public health challenge.

methodsAn 18-month three-site, randomized controlled trial conducted by YMCA staff, with blinded assessors, enrolled 249 older, overweight, and obese adults with either cardiovascular disease or metabolic syndrome with randomization to three interventions: weight loss alone (WL), weight loss + aerobic training (WL + AT), and weight loss + resistance training (WT + RT). The dual primary outcomes were 400-m walk time in seconds and knee extensor strength in Newton meters.

resultsAll groups lost weight from baseline: average baseline adjusted change of -6.1% (95% confidence interval [CI]: -7.5 to -4.7) for WL only, -8.6% (95% CI: -10.0 to -7.2) for WL + AT, and -9.7% (95% CI: -11.1 to -8.4) for WL + RT. Combined, the two physical activity + WL training groups had greater improvement in walk time than WL alone (mean difference 16.9 seconds [95% CI: 9.7 to 24.0], p < .0001). Baseline adjusted change in knee extensor strength was no greater with WL + RT than WL + AT (mean difference -3.6 Nm [95% CI: -7.5 to 0.3], p = .07).

conclusionsAt risk, older, overweight and obese adults can achieve clinically significant reductions in body weight with community-based weight loss programs. The change in percent weight loss and improvements in mobility are significantly enhanced when either RT or AT is combined with dietary WL.

Indexed as

Disability EvaluationQuality of LifeAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedMuscle StrengthObesityResistance TrainingRetrospective StudiesRisk FactorsSingle-Blind MethodWalkingWeight LossObesityPhysical activityResistance trainingWeight loss

Identifiers

PMID28064148
PMCPMC5861918

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.