Evidence map›Paper›PMID 28064014›Full record

ArticleVascular pharmacology2017

GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR-independent suppression of Na

Alexander I Bondarenko, Fabrizio Montecucco, Olga Panasiuk, Vadim Sagach, Nataliya Sidoryak, Karim J Brandt, François Mach

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vascular pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
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  5. Article
  6. Direct activation of CaEuropean journal of pharmacology · 2017
    Article
  7. Article
  8. An Update on Non-CBCannabis and cannabinoid research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Alexander I BondarenkoCirculatory Physiology Department, Bogomoletz Institute of Physiology NAS of Ukraine, Bogomoletz Str.4, 01024 Kiev, Ukraine; Medical University of Graz, Institute of Molecular Biology and Biochemistry, Graz 8010, Austria. Electronic address: abond01@biph.kiev.ua.
Fabrizio MontecuccoFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Largo Benzi 10, 16132 Genoa, Italy.
Olga PanasiukCirculatory Physiology Department, Bogomoletz Institute of Physiology NAS of Ukraine, Bogomoletz Str.4, 01024 Kiev, Ukraine.
Vadim SagachCirculatory Physiology Department, Bogomoletz Institute of Physiology NAS of Ukraine, Bogomoletz Str.4, 01024 Kiev, Ukraine.
Nataliya SidoryakDepartment of Physiology of Human and Animals, Melitopol State Pedagogical University, Ukraine.
Karim J BrandtDivision of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University of Geneva, Av. de la Roseraie 64, CH-1211 Geneva 4, Switzerland.
François MachDivision of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University of Geneva, Av. de la Roseraie 64, CH-1211 Geneva 4, Switzerland.
Bogomoletz Institute of Physiology · UAUniversity of Geneva · CHBogdan Khmelnitsky Melitopol State Pedagogical University · UAMedical University of Graz · ATOspedale Policlinico San Martino · IT

Funding

Austrian Science Fund FWF P 27238Swiss National Science Foundation 152578
6 · The paper itself

Abstract

Lysophosphatidylinositol (LPI) and lysophosphatidylcholine (LPC) are lipid signaling molecules that induce endothelium-dependent vasodilation. In addition, LPC suppresses acetylcholine (Ach)-induced responses. We aimed to determine the influence of LPC and LPI on hyperpolarizing responses in vitro and in situ endothelial cells (EC) and identify the underlying mechanisms. Using patch-clamp method, we show that LPI and LPC inhibit EC hyperpolarization to histamine and suppress Na

Indexed as

AcetylcholineAnimalsAorta, ThoracicCalcium SignalingDose-Response Relationship, DrugEndoplasmic ReticulumEndothelial CellsFemaleHistamineIn Vitro TechniquesLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLysophosphatidylcholinesLysophospholipidsMaleMembrane PotentialsMice, Inbred C57BLAcetylcholineBKCa protein, mouseGPR55 protein, mouseHistamineLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLysophosphatidylcholineslysophosphatidylinositolLysophospholipidsReceptors, CannabinoidSodium-Calcium ExchangerVasodilator AgentsEndothelial cellsHyperpolarizationLysophosphatidylcholineLysophosphatidylinositolNa(+)-Ca(2+) exchanger

Identifiers

PMID28064014
PMCPMC6520228
OpenAlexW2567782006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.