ArticleDevelopmental biology2017
Polarity protein Par3/Bazooka follows myosin-dependent junction repositioning.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- ProTrack3D: a comprehensive tool for segmentation and tracking of proteins with split and fusion.BMC bioinformatics · 2025Article
- Nuclear position controls the activity of cortical actomyosin networks powering simultaneous morphogenetic events.Nature communications · 2025Article
- A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.Molecular biology of the cell · 2024Article
- Adhesion and Polarity protein distribution-regulates hexagon dominated plasma membrane organization in Drosophila blastoderm embryos.Genetics · 2023Article
- Par-3 family proteins in cell polarity & adhesion.The FEBS journal · 2022Review
- Transcriptional Control of Apical-Basal Polarity Regulators.International journal of molecular sciences · 2021Review
- Cellular dynamics of EMT: lessons from live in vivo imaging of embryonic development.Cell communication and signaling : CCS · 2021Review
- Live Imaging of Epithelial-Mesenchymal Transition in Mesoderm Cells of Gastrulating Drosophila Embryos.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium ofeLife · 2020Article
- Self-organized cytoskeletal alignment duringPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Article
- Collective Migrations ofGenetics · 2020Review
- The Physical Mechanisms ofGenetics · 2020Article
- Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity.Nature communications · 2019Article
- TheMolecular biology of the cell · 2019Article
- Article
- Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis.Current opinion in cell biology · 2018Review
- FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity.Development (Cambridge, England) · 2018Article
- Germ layer-specific regulation of cell polarity and adhesion gives insight into the evolution of mesoderm.eLife · 2018Article
- Suppression of epithelial folding at actomyosin-enriched compartment boundaries downstream of Wingless signalling inDevelopment (Cambridge, England) · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The polarity protein Par3/Bazooka (Baz) has been established as a central component of the apical basal polarity system that determines the position of cell-cell junctions in epithelial cells. Consistent with that view, we show that shortly before gastrulation in Drosophila, Baz protein in the mesoderm is down-regulated from junctional sites in response to Snail (Sna) expression. This down-regulation leads to a specific decrease in adherens junctions without affecting other E-Cadherin pools. However, we further show that, interactions between Baz and junctions are not unidirectional. During apical constriction and the internalization of the mesoderm, down-regulation of Baz is transiently blocked as adherens junctions shift apically and are strengthened in response to tension generated by contractile actomyosin. When such junction remodeling is prevented by down-regulating myosin, Baz is lost prematurely in mesodermal epithelium. During such apical shifts, Baz is initially left behind as the junction shifts position, but then re-accumulates at the new location of the junctions. On the dorsal side of the embryo, a similar pattern of myosin activity appears to limit the basal shift in junctions normally driven by Baz that controls epithelium folding. Our results suggest a model where the sensitivity of Baz to Sna expression leads to the Sna-dependent junction disassembly required for a complete epithelium-mesenchymal transition. Meanwhile this loss of Baz-dependent junction maintenance is countered by the myosin-based mechanism which promotes an apical shift and strengthening of junctions accompanied by a transient re-positioning and maintenance of Baz proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.