ArticleJournal of pain and symptom management2017
Could Objective Tests Be Used to Measure Fatigue in Patients With Advanced Cancer?
Article in Journal of pain and symptom management, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial.Breast cancer research and treatment · 2018Trial
- Sarcopenia in Oncological Patients Diagnostics, Screening, and Impact on Quality of Life, Fatigue, Handgrip Strength, and Physical Activity (Sarco-Detect Study).Cancer medicine · 2026Article
- Objective measurement of cancer-related fatigue.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- Instruments for Evaluating the Nutritional Status of Cancer Patients Undergoing Antineoplastic Treatment: A Scoping Review.Nursing reports (Pavia, Italy) · 2024Article
- Assessment of sensorimotor and strength related function of breast cancer patients during systemic drug therapy: a prospective observational study.BMC cancer · 2023Observational
- Relationships between Physiological and Self-Reported Assessment of Cancer-Related Fatigue.International journal of exercise science · 2022Article
- Genetic associations of fatigue and other symptoms following breast cancer treatment: A prospective study.Brain, behavior, & immunity - health · 2021Article
- Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Cancer-Related Fatigue and Muscle Quality in Hodgkin's Lymphoma Survivors.Integrative cancer therapies · 2018Article
- Evaluation of fatigue in patients with pancreatic cancer receiving chemotherapy treatment: a cross-sectional observational study.Acta bio-medica : Atenei Parmensis · 2018Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextAssessment of cancer-related fatigue is currently based on patient-reported outcomes. We asked whether objective assessments, such as muscle strength and nutritional markers, can be used as surrogate measures of cancer-related fatigue.
objectiveWe examined the association among three fatigue scales, muscle strength, and nutritional markers in patients with advanced cancer.
methodsIn this prospective study, we enrolled hospitalized cancer patients who had been seen in palliative care consultation at MD Anderson Cancer Center. We assessed fatigue using three fatigue scales-the Brief Fatigue Inventory (BFI), the Edmonton Symptom Assessment System (ESAS), and the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30)-and determined their association with objective assessments, including handgrip strength, maximal inspiratory pressure, lean body mass, phase angle, and albumin. Spearman's correlation test was used to assess associations.
resultsAmong 222 patients, the mean age was 55 years; 59% were women. The median overall survival was 106 days. The total BFI score had weak association with handgrip strength (ρ = -0.18, P = 0.007) and no association with the remaining objective measures. ESAS fatigue and EORTC fatigue showed similar findings. Total BFI had moderate-to-strong association with ESAS (ρ = 0.54, P < 0.0001) and EORTC (ρ = 0.60, P < 0.0001) fatigue.
conclusionOur study showed that subjective assessment of fatigue based on patient-reported outcomes correlates only weakly with muscle strength and nutritional markers; thus, patient-reported outcomes remain the gold standard for fatigue assessment.
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