ArticleCellular immunology2017
Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.
Article in Cellular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07329595 (Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- The role and therapeutic potential of gut microbiome in severe burn.Frontiers in cellular and infection microbiology · 2022Review
- ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging.Stem cell research & therapy · 2021Article
- Identification of Metagenomics Structure and Function Associated With Temporal Changes in Rat (Rattus norvegicus) Skin Microbiome During Health and Cutaneous Burn.Journal of burn care & research : official publication of the American Burn Association · 2020Article
- Disseminated zoster in an adult patient with extensive burns: a case report.Virology journal · 2019Article
- Low interferon-gamma release in response to phytohemagglutinin predicts the high severity of diseases.Medicine · 2019Article
- Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression.PloS one · 2018Article
- A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome.International journal of molecular sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Following burn injury, a key factor for patients susceptible to opportunistic infections is immune suppression. Butyrate levels are important in maintaining a functional immune system and these levels can be altered after injury. The acid sphingomyelinase (Asm) lipid signaling system has been implicated in a T cell actions with some evidence of being influenced by butyrate. Here, we hypothesized that burn-injury changes in butyrate levels would mediate Asm activity and, consequently, T cell homeostasis. We demonstrate that burn injury temporally decreases butyrate levels. We further determined that T cell Asm activity is increased by butyrate and decreased after burn injury. We additionally observed decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice. Finally, we demonstrate that butyrate reduced T cell death in an Asm-dependent manner. These data suggest that restoration of butyrate after burn injury may ameliorate the T cell lost observed in burn-injured patients by Asm regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.