ArticleeLife2017
Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 81 citations in OpenAlex.
- Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.The Journal of clinical investigation · 2021Trial
- Article
- Vitronectin metabolically programs profibrotic macrophages in 3D cultures and idiopathic pulmonary fibrosis.Science advances · 2026Article
- Influenza coinfection inhibits control of mycobacterial infection in a human challenge model.Nature communications · 2026Article
- The 3D landscape of infection: spatial organization andFrontiers in immunology · 2026Review
- Methodology for a freshly engineered or cryo-preserved 3D tuberculoma bioplatform for studying tuberculosis biology and high-content screening of therapeutics.Frontiers in immunology · 2026Article
- Modeling immune responses of cattle tomSphere · 2025Article
- Iron overload in CD11cCommunications biology · 2025Article
- Interferon-γ Stimulation Fails to Restrict Mycobacterium tuberculosis Growth in Human Monocyte-Derived and Alveolar Macrophages.The Journal of infectious diseases · 2025Article
- 3D Hydrogel Culture System Recapitulates Key Tuberculosis Phenotypes and Demonstrates Pyrazinamide Efficacy.Advanced healthcare materials · 2025Article
- Model systems to studyFrontiers in cellular and infection microbiology · 2025Review
- Experimental dissection of tuberculosis protective immunity: a human perspective.Frontiers in cellular and infection microbiology · 2025Review
- Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the Second International Post-Tuberculosis Symposium.American journal of respiratory and critical care medicine · 2024Review
- Agent-based model predicts that layered structure and 3D movement work synergistically to reduce bacterial load in 3D in vitro models of tuberculosis granuloma.PLoS computational biology · 2024Article
- B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.Communications biology · 2024Article
- An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Myeloid cell expression of CD200R is modulated in active TB disease and regulatesFrontiers in immunology · 2024Article
- Alginate-Based 3D A549 Cell Culture Model to StudyJournal of fungi (Basel, Switzerland) · 2023Article
- Towards using 3D cellular cultures to model the activation and diverse functions of macrophages.Biochemical Society transactions · 2023Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Liku B TezeraNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Magdalena K BieleckaNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Andrew ChancellorNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Michaela T ReichmannNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Basim Al ShammariKing Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Department of Infectious Diseases, MNGHA, Riyadh, Saudi Arabia.
Patience BraceNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Alex BattyNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Annie TochevaNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Sanjay JogaiNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Ben G MarshallNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Marc TebrueggeNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Suwan N JayasingheBioPhysics Group, UCL Institute of Biomedical Engineering, UCL Centre for Stem Cells and Regenerative Medicine and UCL Department of Mechanical Engineering, University College London, London, United Kingdom.
Salah MansourNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Paul T ElkingtonNIHR Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-0390-0613
NIHR Southampton Respiratory Biomedical Research Unit · GBKing Saud bin Abdulaziz University for Health Sciences · SAUCL Biomedical Research Centre · GB
Funding
Targeting matrix metalloproteinases to limit immunopathology in airborne infectioR33AI102239 · NIAID · UNIVERSITY OF SOUTHAMPTON · PI ELKINGTON, PAUL TIMOTHY · 2014 to 2016
$1.1MDepartment of Health DHCS/06/05/012Medical Research Council MR/N006631/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/L001039/1NIAID NIH HHS R33 AI102239
Abstract
Cell biology differs between traditional cell culture and 3-dimensional (3-D) systems, and is modulated by the extracellular matrix. Experimentation in 3-D presents challenges, especially with virulent pathogens.
Indexed as
Models, BiologicalAlginatesAntigens, BacterialBacterial ProteinsChemokine CCL2Chemokine CXCL10Coculture TechniquesCollagenDinoprostoneExtracellular MatrixGene Expression RegulationGlucuronic AcidGranulocyte-Macrophage Colony-Stimulating FactorHexuronic AcidsHost-Pathogen InteractionsHumansAlginatesAntigens, BacterialBacterial ProteinsCCL2 protein, humanCFP-10 protein, Mycobacterium tuberculosisChemokine CCL2Chemokine CXCL10CollagenCXCL10 protein, humanDinoprostoneESAT-6 protein, Mycobacterium tuberculosisGlucuronic AcidGranulocyte-Macrophage Colony-Stimulating FactorHexuronic AcidsIL1B protein, humanInterleukin-12Interleukin-1betabioengineeringextracellular matrixhumanimmunologyinfectious diseasemicrobiologymodellingMycobacterium tuberculosis
Identifiers
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Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.