Evidence map›Paper›PMID 28063205›Full record

ReviewJournal of cellular and molecular medicine2017

Pathogenetic determinants in Kawasaki disease: the haematological point of view.

Domenico Del Principe, Donatella Pietraforte, Lucrezia Gambardella, Alessandra Marchesi, Isabella Tarissi de Jacobis, Alberto Villani, Walter Malorni, Elisabetta Straface

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Markers of Endothelial Dysfunction in Kawasaki Disease: An Update.Clinical reviews in allergy & immunology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Article
  19. [Association of rs4638289 and rs7131332 polymorphisms of the serum amyloid A1 gene with Kawasaki disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Domenico Del PrincipeDepartment of Therapeutic Research and Medicine Evaluation, Section of Cell Aging and Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Donatella PietraforteDepartment of Neurosciences, Section of Cell Aging and Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Lucrezia GambardellaDepartment of Therapeutic Research and Medicine Evaluation, Section of Cell Aging and Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Alessandra MarchesiGeneral Pediatric and Infectious Disease Unit, Internal Care Department, Bambino Gesù Children's Hospital, Rome, Italy.
Isabella Tarissi de JacobisGeneral Pediatric and Infectious Disease Unit, Internal Care Department, Bambino Gesù Children's Hospital, Rome, Italy.
Alberto VillaniGeneral Pediatric and Infectious Disease Unit, Internal Care Department, Bambino Gesù Children's Hospital, Rome, Italy.
Walter MalorniDepartment of Therapeutic Research and Medicine Evaluation, Section of Cell Aging and Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Elisabetta StrafaceDepartment of Therapeutic Research and Medicine Evaluation, Section of Cell Aging and Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Istituto Superiore di Sanità · ITBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronary artery involvement is the most important complication of Kawasaki disease and may cause significant coronary stenosis resulting in ischemic heart disease. The introduction of intravenous immunoglobulin decreases the incidence of coronary artery lesions to less than 5%. The etiopathogenesis of this disease remains unclear. Several lines of evidence suggest that an interplay between a microbial infection and a genetic predisposition could take place in the development of the disease. In this review, we summarize the state of the art of pathogenetic mechanisms of Kawasaki disease underscoring the relevance of haematological features as a novel field of investigation.

Indexed as

BiomarkersHumansImmunityMucocutaneous Lymph Node SyndromePrognosisBiomarkersbiomarkersetiopathogenesisgeneticshaematological featuresimmunityinfectionKawasaki disease

Identifiers

PMID28063205
PMCPMC5345614
OpenAlexW2568243571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.