Evidence map›Paper›PMID 28063075›Full record

Trial reportAIDS and behavior2018

Feasibility and Acceptability of a Task-Shifted Intervention to Enhance Adherence to HIV Medication and Improve Depression in People Living with HIV in Zimbabwe, a Low Income Country in Sub-Saharan Africa.

Melanie Abas, Primrose Nyamayaro, Tarisai Bere, Emily Saruchera, Nomvuyo Mothobi, Victoria Simms, Walter Mangezi, Kirsty Macpherson, Natasha Croome, Jessica Magidson and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05664490 (Youth Friendship Bench SA), which is not on this map. Cited by 66 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05664490 nacompletednot on this mapstarted 2023, after this paper: background citation

Youth Friendship Bench SA: Optimization of the Friendship Bench Mental Health Intervention for Adolescent Girls and Young Women in South African PrEP Delivery Settings

TypeinterventionalSponsorUniversity of California, San FranciscoRan2023 to 2024Enrolled116ConditionsDepression, Pre-Exposure ProphylaxisArmsYouth Friendship Bench SA
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Melanie AbasHealth Service & Population Research Department, Centre for Public Mental Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Box PO 60, De Crespigny Park, London, SE5 8AF, UK. melanie.abas@kcl.ac.uk.ORCID 0000-0003-1716-5584
Primrose NyamayaroCollege of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Tarisai BereZimbabwe AIDS Prevention Project, Department of Community Medicine, University of Zimbabwe, Harare, Zimbabwe.
Emily SarucheraCollege of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Nomvuyo MothobiParirenyatwa General Hospital, Harare, Zimbabwe.
Victoria SimmsDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Walter MangeziCollege of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Kirsty MacphersonHealth Service & Population Research Department, Centre for Public Mental Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Box PO 60, De Crespigny Park, London, SE5 8AF, UK.
Natasha CroomeHealth Service & Population Research Department, Centre for Public Mental Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Box PO 60, De Crespigny Park, London, SE5 8AF, UK.
Jessica MagidsonMassachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Azure MakadzangeMassachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Steven SafrenDepartment of Psychology, University of Miami, Miami, FL, USA.
Dixon ChibandaCollege of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Conall O'CleirighMassachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Funding

Hybrid Effectiveness-Implementation Trial for ART Adherence and Substance Use in HIV Care in South AfricaK23DA041901 · NIDA · UNIV OF MARYLAND, COLLEGE PARK · PI MAGIDSON, JESSICA F · 2016 to 2020
$1.0M
Determinants of Immune Control in HIV perinatally infected children in sub-SaharaK08AI104348 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MAKADZANGE, AZURE TARIRO · 2013 to 2016
$745k
Treatment for depression and adherence in people living with HIV in ZimbabweR21MH094156 · NIMH · KING'S COLLEGE LONDON · PI ABAS, MELANIE AMNA, CHIBANDA, DICKSON · 2013 to 2014
$221k
NIAID NIH HHS K08 AI104348NIDA NIH HHS K23 DA041901NIMH NIH HHS 1R21MH094156-01A1NIMH NIH HHS R21 MH094156
6 · The paper itself

Abstract

Using a pilot trial design in an HIV care clinic in Zimbabwe, we randomised 32 adults with poor adherence to antiretroviral therapy and at least mild depression to either six sessions of Problem-Solving Therapy for adherence and depression (PST-AD) delivered by an adherence counsellor, or to Enhanced Usual Care (Control). Acceptability of PST-AD was high, as indicated by frequency of session attendance and through qualitative analyses of exit interviews. Fidelity was >80% for the first two sessions of PST-AD but fidelity to the adherence component of PST-AD dropped by session 4. Contamination occurred, in that seven patients in the control arm received one or two PST-AD sessions before follow-up assessment. Routine health records proved unreliable for measuring HIV viral load at follow-up. Barriers to measuring adherence electronically included device failure and participant perception of being helped by the research device. The study was not powered to detect clinical differences, however, promising change at 6-months follow-up was seen in electronic adherence, viral load suppression (PST-AD arm 9/12 suppressed; control arm 4/8 suppressed) and depression (Patient Health Questionnaire-4.7 points in PST-AD arm vs. control, adjusted p value = 0.01). Results inform and justify a future randomised controlled trial of task-shifted PST-AD.

Indexed as

Problem SolvingAdultCognitive Behavioral TherapyDepressionFeasibility StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedPatient Acceptance of Health CarePersonnel Staffing and SchedulingProgram EvaluationZimbabweAdherenceDepressionInterventionProblem solvingSub-Saharan Africa

Identifiers

PMID28063075
PMCPMC5758696

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.