ArticleNeuroradiology2017
Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor.
Article in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- Modulation of Lingo-1 and NMDA receptor expression by memantine and vitamin D3 co-therapy attenuates motor and non-motor symptoms in essential tremor.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Transcranial static magnetic field stimulation of the primary motor cortex in essential tremor: a randomized pilot study.NPJ Parkinson's disease · 2025Article
- Neuroscience of human ventral lateral thalamic nucleus related to movement and movement disorders.Journal of neurophysiology · 2025Review
- The cerebellar involvement in essential tremor: the connecting roads.Arquivos de neuro-psiquiatria · 2025Review
- Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways.BMC neuroscience · 2025Article
- Microstructural abnormalities of the dentato-rubro-thalamo-cortical tract in tremor dominant Parkinson's disease and essential tremor plus syndrome.Neuroradiology · 2025Article
- Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor.Journal of biomedical science · 2025Review
- Identification of a metabolic brain network characterizing essential tremor.Scientific reports · 2025Article
- Thalamic and Visual Network Dysfunction Relates to Tremor Response in Thalamic Deep Brain Stimulation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- The Role of Cerebellum and Basal Ganglia Functional Connectivity in Altered Voluntary Movement Execution in Essential Tremor.Cerebellum (London, England) · 2024Article
- Differential patterns of functional connectivity in tremor dominant Parkinson's disease and essential tremor plus.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Protocol for a Phase 2 randomized controlled patient-assessor blinded study: efficacy and safety of combined cortical and cerebellar dual-target transcranial magnetic stimulation for the treatment of essential tremor.Frontiers in neurology · 2024Article
- Cognitive outcomes in patients with essential tremor treated with deep brain stimulation: a systematic review.Frontiers in human neuroscience · 2024Review
- Deep brain stimulation does not modulate resting-state functional connectivity in essential tremor.Brain communications · 2024Article
- Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis.Neurology · 2023Review
- Identification of essential tremor based on resting-state functional connectivity.Human brain mapping · 2023Article
- Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling.NeuroImage. Clinical · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEssential tremor (ET) is the most common movement disorder among adults. Although ET has been recognized as a mono-symptomatic benign illness, reports of non-motor symptoms and non-tremor motor symptoms have increased its clinical heterogeneity. The neural correlates of ET are not clearly understood. The aim of this study was to understand the neurobiology of ET using resting state fMRI.
methodsResting state functional MR images of 30 patients with ET and 30 age- and gender-matched healthy controls were obtained. The functional connectivity of the two groups was compared using whole-brain seed-to-voxel-based analysis.
resultsThe ET group had decreased connectivity of several cortical regions especially of the primary motor cortex and the primary somatosensory cortex with several right cerebellar lobules compared to the controls. The thalamus on both hemispheres had increased connectivity with multiple posterior cerebellar lobules and vermis. Connectivity of several right cerebellar seeds with the cortical and thalamic seeds had significant correlation with an overall score of Fahn-Tolosa-Marin tremor rating scale (FTM-TRS) as well as the subscores for head tremor and limb tremor.
conclusionSeed-to-voxel resting state connectivity analysis revealed significant alterations in the cerebello-thalamo-cortical network in patients with ET. These alterations correlated with the overall FTM scores as well as the subscores for limb tremor and head tremor in patients with ET. These results further support the previous evidence of cerebellar pathology in ET.
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