ArticleJournal of pain and symptom management2017
Symptom Clusters Change Over Time in Women Receiving Adjuvant Chemotherapy for Breast Cancer.
Article in Journal of pain and symptom management, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Effectiveness of Interventions Based on Symptom Clusters for Symptom Burden and Quality of Life Among Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.Research in nursing & health · 2026Pooled it
- Symptom clusters and their temporal patterns in breast cancer patients undergoing chemotherapy: a systematic review of cross-sectional and longitudinal studies.Frontiers in oncology · 2026Pooled it
- Exploring Symptom Cluster Patterns in Adult Cancer Patients Undergoing Chemotherapy: A Systematic Review.Journal of Korean Academy of Nursing · 2024Pooled it
- Symptom clusters in patients receiving chemotherapy: A systematic review.BMJ supportive & palliative care · 2022Pooled it
- Symptom clusters experienced by breast cancer patients at various treatment stages: A systematic review.Cancer medicine · 2021Pooled it
- Impact of early multidisciplinary team interventions on dietary management behavior in breast cancer patients: a pilot randomized controlled trial.BMC cancer · 2025Trial
- Long-Term Favorable Effects of Physical Exercise on Burdensome Symptoms in the OptiTrain Breast Cancer Randomized Controlled Trial.Integrative cancer therapiesTrial
- Article
- Latent profile analysis for assessing symptom clusters in women with breast cancer.Journal of cancer survivorship : research and practice · 2026Article
- Health Related Quality of Life Among Women with Breast Cancer in Mogadishu, Somalia.Breast cancer (Dove Medical Press) · 2026Article
- Identifying Core Symptoms in Breast Cancer Patients with Different Chemotherapy Phases Using Network Analysis: A Prospective Multicenter Longitudinal Study.Patient preference and adherence · 2026Article
- Navigating specific targets of psychoneurological symptom cluster in breast cancer: a computer-simulated network analysis.Frontiers in oncology · 2026Article
- Symptom Clusters in Brazilian Women With Stage I and Stage III Nonmetastatic Breast Cancer: A Cross-Sectional Study.The breast journal · 2026Article
- Medical and psychosocial symptom clusters and their temporal patterns in people with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Symptom Clusters and Their Impact on Spiritual Well-Being Among Women with Breast Cancer.International journal of women's health · 2024Article
- Symptom clusters among breast cancer patients in relation to chemotherapy cycles: a longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- The effect of spiritual well-being on symptom experience in patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Factors associated with sleep disturbances in women undergoing treatment for early-stage breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study.BMC cancer · 2021Article
- A Proposed Theory of Symptom Cluster Management.Belitung nursing journal · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
contextPatients with breast cancer receiving chemotherapy (CTX) experience multiple concurrent symptoms, but little is known about how symptoms change during and after treatment. Knowledge of the identity and trajectory of symptom clusters (SCs) would enhance measurement and management.
objectivesWe aimed to identify SCs and their change over time from baseline to completion of breast cancer CTX.
methodsSCs were identified and assessed for change in 219 women from Nebraska at four times: baseline, during cycles #3 and #4 of CTX, and one month after finishing CTX. Ten symptoms were measured: two using the Hospital Anxiety and Depression Scale and eight using the Symptom Experience Scale. Exploratory factor analysis was conducted at each time point, then changes in SCs were evaluated at different times.
resultsTwo SCs were identified before and after initiating CTX: gastrointestinal and treatment-related. The number and type of symptoms in each cluster differed over time. Clusters were dynamic during CTX with changes in the number and type of symptoms. Only one treatment-related SC, which consisted of fatigue, pain, and sleep disturbance, was identified after CTX completion.
conclusionSCs during CTX appear to be dynamic, changing over time from before until after CTX completion. Repeated assessments of SCs reveal symptoms that are present and when patients are most burdened and in need of additional support.
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