ArticleAmerican journal of preventive medicine2017
Disclosing Genetic Risk for Coronary Heart Disease: Attitudes Toward Personal Information in Health Records.
Article in American journal of preventive medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Reshaping Precision Cancer Pain Management with Multimodal Artificial Intelligence: A Review on Subtyping and Treatment Response Prediction.Journal of pain research · 2026Review
- Strategic insights into pharmacogenomics coverage: a theory-informed SWOT analysis of UAE insurance stakeholders' perspectives.Human genomics · 2025Article
- Simplified rules-based tool to facilitate the application of up-to-date management recommendations in cardio-oncology.Cardio-oncology (London, England) · 2023Article
- Impact of Electronic Health Records on Information Practices in Mental Health Contexts: Scoping Review.Journal of medical Internet research · 2022Article
- How do patients value and prioritize patient portal functionalities and usage factors? A conjoint analysis study with chronically ill patients.BMC medical informatics and decision making · 2018Article
- A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine.Yearbook of medical informatics · 2017Review
- Disease characteristics influence the privacy calculus to adopt electronic health records: A survey study in Germany.Digital healthArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionIncorporating genetic risk information in electronic health records (EHRs) will facilitate implementation of genomic medicine in clinical practice. However, little is known about patients' attitudes toward incorporation of genetic risk information as a component of personal health information in EHRs. This study investigated whether disclosure of a genetic risk score (GRS) for coronary heart disease influences attitudes toward incorporation of personal health information including genetic risk in EHRs.
methodsParticipants aged 45-65 years with intermediate 10-year coronary heart disease risk were randomized to receive a conventional risk score (CRS) alone or with a GRS from a genetic counselor, followed by shared decision making with a physician using the same standard presentation and information templates for all study participants. The CRS and GRS were then incorporated into the EHR and made accessible to both patients and physicians. Baseline and post-disclosure surveys were completed to assess whether attitudes differed by GRS disclosure. Data were collected from 2013 to 2015 and analyzed in 2015-2016.
resultsGRS and CRS participants reported similar positive attitudes toward incorporation of genetic risk information in the EHR. Compared with CRS participants, participants with high GRS were more concerned about the confidentiality of genetic risk information (OR=3.67, 95% CI=1.29, 12.32, p=0.01). Post-disclosure, frequency of patient portal access was associated with positive attitudes.
conclusionsParticipants in this study of coronary heart disease risk disclosure overall had positive attitudes toward incorporation of genetic risk information in EHRs, although those who received genetic risk information had concerns about confidentiality.
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