ArticleDevelopmental and comparative immunology2017
Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss).
Article in Developmental and comparative immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- Comparative analysis of the immune responses of CcIgZ3 in mucosal tissues and the co-expression of CcIgZ3 and PCNA in the gills of common carp (Cyprinus carpio L.) in response to TNP-LPS.BMC veterinary research · 2024Article
- Distinct distribution and responses of IgMFrontiers in immunology · 2024Article
- The Immune Response to the Myxozoan ParasiteInternational journal of molecular sciences · 2023Review
- Monoclonal antibody generated against Nile tilapia (Fish and shellfish immunology reports · 2023Article
- Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments.EMBO reports · 2023Article
- Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish.iScience · 2021Article
- Article
- A long reads-based de-novo assembly of the genome of the Arlee homozygous line reveals chromosomal rearrangements in rainbow trout.G3 (Bethesda, Md.) · 2021Article
- Molecular characterization of a new IgZ3 subclass in common carp (Cyprinus carpio) and comparative expression analysis of IgH transcripts during larvae development.BMC veterinary research · 2021Article
- Differential immune responses of immunoglobulin Z subclass members in antibacterial immunity in a zebrafish model.Immunology · 2021Article
- Quantitative trait loci (QTL) associated with resistance of rainbow trout Oncorhynchus mykiss against the parasitic ciliate Ichthyophthirius multifiliis.Journal of fish diseases · 2020Article
- Transient increase in abundance of B lineage but not myeloid-lineage cells in anterior kidney of sockeye salmon during return migration to the natal grounds.Fish & shellfish immunology · 2020Article
- Article
- Immune response to Ichthyophthirius multifiliis and role of IgT.Parasite immunology · 2020Review
- Development of a Monoclonal Antibody Specific to the IgM Heavy Chain of Bighead Catfish (Biomolecules · 2020Article
- A Major QTL for Resistance toFrontiers in genetics · 2020Article
- Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish.Frontiers in immunology · 2020Review
- Deiminated proteins in extracellular vesicles and serum of llama (Lama glama)-Novel insights into camelid immunity.Molecular immunology · 2020Article
- Profiling Atlantic salmon B cell populations: CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression.Scientific reports · 2018Article
- Perspective on the Development and Validation of Ab Reagents to Fish Immune Proteins for the Correct Assessment of Immune Function.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
As the teleost specific immunoglobulin, IgT plays important roles in systemic and mucosal immunity. In the current study, in rainbow trout, we have cloned the heavy chain (Igτ) genes of a secretory form of IgT2 as well as the membrane and secretory forms of a third IgT subclass, termed IgT3. Conserved cysteine and tryptophan residues that are crucial for the folding of the immunoglobulin domain as well as hydrophobic and hydrophilic residues within CART motif were identified in all IgT subclasses. Through analysis of the rainbow trout genome assembly, Igτ3 gene was found localized upstream of Igτ1 gene, while Igτ2 gene situated on another scaffold. At the transcriptional level, Igτ1 was mainly expressed in both systemic and mucosal lymphoid tissues, while Igτ2 was largely expressed in systemic lymphoid organs. After LPS and poly (I:C) treatment, Igτ1 and Igτ2 genes exhibited different expression profiles. Interestingly the transcriptional level of Igτ3 was negligible, although its protein product could be identified in trout serum. Importantly, a previously reported monoclonal antibody directed against trout IgT1 was able to recognize IgT2 and IgT3. These data demonstrate that there exist three subclasses of IgT in rainbow trout, and that their heavy chain genes display different expression patterns during stimulation. Overall, our data reflect the diversity and complexity of immunoglobulin in trout, thus provide a better understanding of the IgT system in the immune response of teleost fish.
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