Evidence map›Paper›PMID 28062081›Full record

ArticleThe American journal of pathology2017

Neonatal Hypoxia Results in Peripheral Nerve Abnormalities.

Benjamin L L Clayton, Aaron Huang, Danuta Dukala, Betty Soliven, Brian Popko

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Benjamin L L ClaytonDepartment of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
Aaron HuangDepartment of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
Danuta DukalaDepartment of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
Betty SolivenDepartment of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
Brian PopkoDepartment of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois. Electronic address: bpopko@neurology.bsd.uchicago.edu.
University of Chicago · US

Funding

Targeting the integrated stress response to protect oligodendrocyte lineage cells - Resubmission 01R01NS034939 · NINDS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI POPKO, BRIAN J · 1997 to 2024
$7.5M
NINDS NIH HHS R01 NS034939
6 · The paper itself

Abstract

Although the adverse effects of neonatal hypoxia associated with premature birth on the central nervous system are well known, the contribution of hypoxic damage to the peripheral nervous system (PNS) has not been addressed. We demonstrate that neonatal hypoxia results in hypomyelination and delayed axonal sorting in mice leading to electrophysiological and motor deficits that persist into adulthood. These findings support a potential role for PNS hypoxic damage in the motor impairment that results from premature birth and suggest that therapies designed to protect the PNS may provide clinical benefit.

Indexed as

AnimalsAnimals, NewbornAxonsDisease Models, AnimalElectrophysiologyFemaleHypoxiaImmunohistochemistryMaleMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionMyelin SheathReal-Time Polymerase Chain ReactionSciatic Nerve

Identifiers

PMID28062081
PMCPMC5397665
OpenAlexW2570016828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.