ArticleParasites & vectors2017
Epidemiology of Mansonella perstans in the middle belt of Ghana.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02281643 (Comparison of Early and Late Administration of Doxycycline in Their Efficacy Against Mansonella Perstans and in Development of Immunity Against Mycobacterial Infections), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Early and Late Administration of Doxycycline in Their Efficacy Against Mansonella Perstans and in Development of Immunity Against Mycobacterial Infections
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The Efficacy of Doxycycline Treatment onThe American journal of tropical medicine and hygiene · 2019Trial
- Molecular Epidemiology of Skin-Dwelling Filariae and Risk Factors for Mansonella streptocerca Infection, Gabon.Emerging infectious diseases · 2026Article
- Usability, acceptability, and cost of the SD BIOLINE Ov16 rapid diagnostic test for onchocerciasis surveillance in endemic communities in the middle belt of Ghana.PLoS neglected tropical diseases · 2025Article
- Wolbachia bacteria in Mansonella perstans isolates from patients infected in different geographical areas: a pilot study from the ESCMID Study Group for Clinical Parasitology.Parasites & vectors · 2025Article
- Association of haemato-biochemical indices and blood composite ratios with microfilaridermia in Onchocerciasis patients.BMC infectious diseases · 2024Article
- Diversity of Culicoides in the middle belt of Ghana with Implications on the transmission of Mansonella perstans; a molecular approach.Parasites & vectors · 2024Article
- Article
- Identification and characterisation of Mansonella perstans in the Volta Region of Ghana.PloS one · 2024Article
- Very low prevalence of Mansonella perstans-specific cell-free DNA in serum samples of Ghanaian HIV patients.European journal of microbiology & immunology · 2023Article
- A large case series of travel-related Mansonella perstans (vector-borne filarial nematode): a TropNet study in Europe.Journal of travel medicine · 2022Article
- Occurrence of Lymphatic Filariasis infection after 15 years of mass drug administration in two hotspot districts in the Upper East Region of Ghana.PLoS neglected tropical diseases · 2022Article
- Characterising co-infections with Plasmodium spp., Mansonella perstans or Loa loa in asymptomatic children, adults and elderly people living on Bioko Island using nucleic acids extracted from malaria rapid diagnostic tests.PLoS neglected tropical diseases · 2022Article
- Field evaluation of DNA detection of human filarial and malaria parasites using mosquito excreta/feces.PLoS neglected tropical diseases · 2020Article
- Blood-meal analysis of Culicoides (Diptera: Ceratopogonidae) reveals a broad host range and new species records for Romania.Parasites & vectors · 2020Article
- Assessment of multiplex Onchocerca volvulus peptide ELISA in non-endemic tropical regions.Parasites & vectors · 2019Article
- Updating the global occurrence of Culicoides imicola, a vector for emerging viral diseases.Scientific data · 2019Article
- Update on the biology and ecology of Culicoides species in the South-West region of Cameroon with implications on the transmission of Mansonella perstans.Parasites & vectors · 2019Article
- DNA barcoding and molecular identification of field-collected Culicoides larvae in the Niayes area of Senegal.Parasites & vectors · 2018Article
- Mansonellosis, the most neglected human filariasis.New microbes and new infections · 2018Review
- Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundMansonellosis was first reported in Ghana by Awadzi in the 1990s. Co-infections of Mansonella perstans have also been reported in a small cohort of patients with Buruli ulcer and their contacts. However, no study has assessed the exact prevalence of the disease in a larger study population. This study therefore aimed to find out the prevalence of M. perstans infection in some districts in Ghana and to determine the diversity of Culicoides that could be potential vectors for transmission.
methodsFrom each participant screened in the Asante Akim North (Ashanti Region), Sene West and Atebubu Amantin (Brong Ahafo Region) districts, a total of 70 μl of finger prick blood was collected for assessment of M. perstans microfilariae. Centre for Disease Control (CDC) light traps as well as the Human Landing Catch (HLC) method were used to assess the species diversity of Culicoides present in the study communities.
resultsFrom 2,247 participants, an overall prevalence of 32% was recorded although up to 75% prevalence was demonstrated in some of the communities. Culicoides inornatipennis was the only species of Culicoides caught with the HLC method. By contrast, C. imicola (47%), C. neavei (25%) and C. schultzei (15%) were caught by the CDC light trap method. A wide diversity of other Culicoides spp. was also identified but correlation was only found between the prevalence of C. inornatipennis and M. perstans during the dry season.
conclusionsHere we demonstrate for the first time that M. perstans is highly prevalent in three districts in Ghana. We found a wide spectrum of Culicoides spp. Culicoides inornatipennis was the most anthropophilic and is therefore likely to be the species responsible for transmission of infection but formal proof has yet to be obtained.
trial registrationNCT02281643 . Registered October 26, 2014. 'Retrospectively registered'. TRIAL REGISTRY: ClinicalTrials.gov.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.