ArticleBMC public health2017
Risk factors for mortality in TB patients: a 10-year electronic record review in a South African province.
Article in BMC public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of risk factors for mortality among tuberculosis patients in South Africa.Systematic reviews · 2023Pooled it
- Predictors of tuberculosis mortality among patients on treatment: A retrospective cohort study at a rural general hospital in Zambia.PloS one · 2026Article
- Article
- Tuberculosis Trends in the Post-COVID-19 Era: Is It Going to be a Global Concern?Health science reports · 2025Article
- High mortality among patients with tuberculosis accessing primary care facilities: secondary analysis from an open-label cluster-randomised trial.EClinicalMedicine · 2025Article
- Clinico-radiological characteristics and lethality of HIV-tuberculosis coinfection in the Infectiology ward of the Libreville University Hospital, Gabon.Southern African journal of infectious diseases · 2025Article
- Predicting and improving diagnosis of tuberculosis outcomes in South Africa using machine learning techniques.PLOS global public health · 2025Article
- Mortality and loss to follow-up among Tuberculosis patients on treatment in Meru County, Kenya: a retrospective cohort study.PLOS global public health · 2025Article
- Association between TB delay and TB treatment outcomes in HIV-TB co-infected patients: a study based on the multilevel propensity score method.BMC infectious diseases · 2024Article
- Mortality among persons with tuberculosis in Zambian hospitals: A retrospective cohort study.PLOS global public health · 2024Article
- Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort.The European respiratory journal · 2023Article
- Predictors of mortality and survival probability distribution among patients on tuberculosis treatment in Vihiga County, Kenya.African health sciences · 2023Article
- The survival analysis of rifampicin/multidrug-resistant tuberculosis patients based on the levels of inflammatory biomarkers: a retrospective cohort study.Frontiers in cellular and infection microbiology · 2023Article
- Mortality among persons receiving tuberculosis treatment in Itezhi-Tezhi District of Zambia: A retrospective cohort study.PLOS global public health · 2023Article
- Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique.Scientific reports · 2022Article
- Investigating Spatial Patterns of Pulmonary Tuberculosis and Main Related Factors in Bandar Lampung, Indonesia Using Geographically Weighted Poisson Regression.Tropical medicine and infectious disease · 2022Article
- Tuberculosis control at a South African correctional centre: Diagnosis, treatment and strain characterisation.PloS one · 2022Observational
- Mortality and associated factors among adult patients on tuberculosis treatment in Tanzania: A retrospective cohort study.Journal of clinical tuberculosis and other mycobacterial diseases · 2021Article
- The risk of pulmonary tuberculosis after traumatic brain injury.Scientific reports · 2021Article
- Mortality in South African Children and Adolescents Routinely Treated for Tuberculosis.Pediatrics · 2021Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince 1990, reduction of tuberculosis (TB) mortality has been lower in South Africa than in other high-burden countries in Africa. This research investigated the influence of routinely captured demographic and clinical or programme variables on death in TB patients in the Free State Province.
methodsA retrospective review of case information captured in the Electronic TB register (ETR.net) over the years 2003 to 2012 was conducted. Extracted data were subjected to descriptive and logistic regression analyses. The outcome variable was defined as all registered TB cases with 'died' as the recorded outcome. The variables associated with increased or decreased odds of dying in TB patients were established. The univariate and adjusted odds ratios (OR and AOR) together with their corresponding 95% confidence intervals (CI) were estimated, taking the clustering effect of the districts into account.
resultsOf the 190,472 TB cases included in the analysis, 30,991 (16.3%) had 'died' as the recorded treatment outcome. The proportion of TB patients that died increased from 15.1% in 2003 to 17.8% in 2009, before declining to 15.4% in 2012. The odds of dying was incrementally higher in the older age groups: 8-17 years (AOR: 2.0; CI: 1.5-2.7), 18-49 years (AOR: 5.8; CI: 4.0-8.4), 50-64 years (AOR: 7.7; CI: 4.6-12.7), and ≥65 years (AOR: 14.4; CI: 10.3-20.2). Other factors associated with increased odds of mortality included: HIV co-infection (males - AOR: 2.4; CI: 2.1-2.8; females - AOR: 1.9; CI: 1.7-2.1) or unknown HIV status (males - AOR: 2.8; CI: 2.5-3.1; females - AOR: 2.4; CI: 2.2-2.6), having a negative (AOR: 1.4; CI: 1.3-1.6) or a missing (AOR: 2.1; CI: 1.4-3.2) pre-treatment sputum smear result, and being a retreatment case (AOR: 1.3; CI: 1.2-1.4).
conclusionsAlthough mortality in TB patients in the Free State has been falling since 2009, it remained high at more than 15% in 2012. Appropriately targeted treatment and care for the identified high-risk groups could be considered.
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