Evidence map›Paper›PMID 28061371›Full record

ArticleEnvironmental research2017

Low-level arsenic exposure via drinking water consumption and female fecundity - A preliminary investigation.

Michele L Susko, Michael S Bloom, Iulia A Neamtiu, Allison A Appleton, Simona Surdu, Cristian Pop, Edward F Fitzgerald, Doru Anastasiu, Eugen S Gurzau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Michele L SuskoDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, United States.
Michael S BloomDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, United States; Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, New York, United States. Electronic address: mbloom@albany.edu.
Iulia A NeamtiuHealth Department, Environmental Health Center, Cluj-Napoca, Romania; IMOGEN Research Institute, Cluj-Napoca, Romania.
Allison A AppletonDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, United States.
Simona SurduDepartment of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, New York, United States.
Cristian PopPhysico-chemical and Biotoxicological Analysis Laboratory, Environmental Health Center, Cluj-Napoca, Romania; Cluj School of Public Health - College of Political, Administrative and Communication Sciences, Babeṣ-Bolyai University, Cluj-Napoca, Romania; Faculty of Environmental Science and Engineering, Babeṣ-Bolyai University, Cluj-Napoca, Romania.
Edward F FitzgeraldDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, United States; Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, New York, United States.
Doru AnastasiuUniversity of Medicine and Pharmacy "Victor Babeṣ", Timiṣoara, Romania; Obstetrics and Gynecology Department of the Emergency County Hospital, Timiṣoara, Romania.
Eugen S GurzauHealth Department, Environmental Health Center, Cluj-Napoca, Romania; IMOGEN Research Institute, Cluj-Napoca, Romania; University of Medicine and Pharmacy "Iuliu Haṭieganu", Cluj-Napoca, Romania.
University at Albany, State University of New York · USAlbany State University · USTechnical University of Cluj-Napoca · ROBabeș-Bolyai University · ROVictor Babeș University of Medicine and Pharmacy Timișoara · RO

Funding

Developmental Infrastructure CoreR24HD044943 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI DENTON, NANCY A · 2004 to 2016
$4.8M
Arsenic Contaminated Water Consumption & Spontaneous Pregnancy Loss in RomaniaR03ES020446 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI BLOOM, MICHAEL S · 2011 to 2012
$151k
NICHD NIH HHS R24 HD044943NIEHS NIH HHS R03 ES020446
6 · The paper itself

Abstract

High level arsenic exposure is associated with reproductive toxicity in experimental and observational studies; however, few data exist to assess risks at low levels. Even less data are available to evaluate the impact of low level arsenic exposure on human fecundity. Our aim in this pilot study was a preliminary evaluation of associations between low level drinking water arsenic contamination and female fecundity. This retrospective study was conducted among women previously recruited to a hospital-based case-control study of spontaneous pregnancy loss in Timiṣ County, Romania. Women (n=94) with planned pregnancies of 5-20 weeks gestation completed a comprehensive physician-administered study questionnaire and reported the number of menstrual cycles attempting to conceive as the time to pregnancy (TTP). Drinking water samples were collected from residential drinking water sources and we determined arsenic levels using hydride generation-atomic absorption spectrometry (HG-AAS). Multivariable Cox-proportional hazards regression with Efron approximation was employed to evaluate TTP as a function of drinking water arsenic concentrations among planned pregnancies, adjusted for covariates. There was no main effect for drinking water arsenic exposure, yet the conditional probability for pregnancy was modestly lower among arsenic exposed women with longer TTPs, relative to women with shorter TTPs, and relative to unexposed women. For example, 1µg/L average drinking water arsenic conferred 5%, 8%, and 10% lower likelihoods for pregnancy in the 6th, 9th, and 12th cycles, respectively (P=0.01). While preliminary, our results suggest that low level arsenic contamination in residential drinking water sources may further impair fecundity among women with longer waiting times; however, this hypothesis requires confirmation by a future, more definitive study.

Indexed as

AdultArsenicCohort StudiesDrinking WaterFemaleFertilityHumansMaternal AgePilot ProjectsPregnancyRetrospective StudiesRomaniaSocioeconomic FactorsTime FactorsTime-to-PregnancyWater Pollutants, ChemicalArsenicDrinking WaterWater Pollutants, ChemicalArsenicFecundityPregnancyReproductionRomaniaWater

Identifiers

PMID28061371
PMCPMC5328919
OpenAlexW2568919271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.