ArticleJournal of biomedical optics2017
Mapping optical path length and image enhancement using quantitative orientation-independent differential interference contrast microscopy.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- A correlative quantitative phase contrast and fluorescence super-resolution microscope for imaging molecules in their cellular context.bioRxiv : the preprint server for biology · 2025Article
- Spatial microfluidic holographic integrated platform for label-free and high-dimensional analysis of cancer heterogeneity.Nature communications · 2025Article
- Live-cell imaging under centrifugation characterized the cellular force for nuclear centration in theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Orientation-independent-DIC imaging reveals that a transient rise in depletion attraction contributes to mitotic chromosome condensation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multispectral Holographic Intensity and Phase Imaging of Semitransparent Ultrathin Films.ACS photonics · 2024Article
- Quantitative phase imaging by gradient retardance optical microscopy.Scientific reports · 2024Article
- Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation.bioRxiv : the preprint server for biology · 2024Article
- Live-cell imaging under centrifugation characterized the cellular force for nuclear centration in thebioRxiv : the preprint server for biology · 2024Article
- Polarization differential interference contrast microscopy with physics-inspired plug-and-play denoiser for single-shot high-performance quantitative phase imaging.Biomedical optics express · 2023Article
- Using Advanced Differential Interference Contrast Microscopy for High-Resolution Mapping Two-Dimensional Phase Distribution in Cells and Tissue Structures.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2019Article
- Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells.Scientific reports · 2019Article
- An orientation-independent DIC microscope allows high resolution imaging of epithelial cell migration and wound healing in a cnidarian model.Journal of microscopy · 2018Article
- Revealing chiral cell motility by 3D Riesz transform-differential interference contrast microscopy and computational kinematic analysis.Nature communications · 2017Article
- Density imaging of heterochromatin in live cells using orientation-independent-DIC microscopy.Molecular biology of the cell · 2017Article
- Gradient light interference microscopy for 3D imaging of unlabeled specimens.Nature communications · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
We describe the principles of using orientation-independent differential interference contrast (OI-DIC) microscopy for mapping optical path length (OPL). Computation of the scalar two-dimensional OPL map is based on an experimentally received map of the OPL gradient vector field. Two methods of contrast enhancement for the OPL image, which reveal hardly visible structures and organelles, are presented. The results obtained can be used for reconstruction of a volume image. We have confirmed that a standard research grade light microscope equipped with the OI-DIC and 100 × / 1.3 NA objective lens, which was not specially selected for minimum wavefront and polarization aberrations, provides OPL noise level of ? 0.5 ?? nm and lateral resolution if ? 300 ?? nm at a wavelength of 546 nm. The new technology is the next step in the development of the DIC microscopy. It can replace standard DIC prisms on existing commercial microscope systems without modification. This will allow biological researchers that already have microscopy setups to expand the performance of their systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.