ArticlePLoS pathogens2017
The TIR Homologue Lies near Resistance Genes in Staphylococcus aureus, Coupling Modulation of Virulence and Antimicrobial Susceptibility.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Targeting cGAS-STING signaling to overcome antibiotic-resistant bacterial infections: Challenges and opportunities.Science advances · 2026Review
- Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment.Nature reviews. Microbiology · 2026Review
- TLR5 influences the development of type 1 diabetes.BMJ open diabetes research & care · 2025Article
- From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments.Frontiers in immunology · 2025Review
- SARM1 in the pathogenesis of immune-related disease.Toxicology research · 2024Review
- Exploring the Accessory Genome of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Characterisation of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions.Molecules (Basel, Switzerland) · 2022Article
- Characterisation of S. aureus/MRSA CC1153 and review of mobile genetic elements carrying the fusidic acid resistance gene fusC.Scientific reports · 2021Article
- A Murine Skin Infection Model Capable of Differentiating the Dermatopathology of Community-Associated MRSA Strain USA300 from Other MRSA Strains.Microorganisms · 2021Article
- Immunopathogenesis of Craniotomy Infection and Niche-Specific Immune Responses to Biofilm.Frontiers in immunology · 2021Review
- Vaginal Tampon Colonization by Staphylococcus aureus in Healthy Women.Applied and environmental microbiology · 2020Article
- TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection.Journal of neuroinflammation · 2020Article
- Association of characteristics of tampon use with menstrual toxic shock syndrome in France.EClinicalMedicine · 2020Article
- The TIR-domain containing effectors BtpA and BtpB from Brucella abortus impact NAD metabolism.PLoS pathogens · 2020Article
- AInternational journal of molecular sciences · 2019Article
- Characterisation of a novel SCCmec VI element harbouring fusC in an emerging Staphylococcus aureus strain from the Arabian Gulf region.PloS one · 2019Article
- Complex ecological interactions of Staphylococcus aureus in tampons during menstruation.Scientific reports · 2018Article
- TIR Domain Proteins Are an Ancient Family of NADCurrent biology : CB · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacterial invasion mechanism. Its ectopic expression in eukaryotic cells inhibited TLR signaling, downregulating the NF-kB pathway through inhibition of TLR2, TLR4, TLR5, and TLR9. Skin lesions induced by the S. aureus knockout tirS mutant increased in a mouse model compared with wild-type and restored strains even though the tirS-mutant and wild-type strains did not differ in bacterial load. TirS also was associated with lower neutrophil and macrophage activity, confirming a central role in virulence attenuation through local inflammatory responses. TirS invariably localizes within the staphylococcal chromosomal cassettes (SCC) containing the fusC gene for fusidic acid resistance but not always carrying the mecA gene. Of note, sub-inhibitory concentration of fusidic acid increased tirS expression. Epidemiological studies identified no link between this effector and clinical presentation but showed a selective advantage with a SCCmec element with SCC fusC/tirS. Thus, two key traits determining the success and spread of bacterial infections are linked.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.