ArticlePloS one2017
Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Association of longitudinal thyroid function parameters with preterm birth: a retrospective cohort study in Jinan, China.BMC pregnancy and childbirth · 2026Article
- Integrated metagenomic and metabolomic profiling of spontaneous preterm birth in Chinese women.Frontiers in microbiology · 2026Article
- Effects of Maternal Hypothyroidism on Preterm Labor and Neonatal Outcomes: A Prospective Case-control Study.Annals of African medicine · 2026Article
- Association between levothyroxine supplementation for hypothyroidism in late pregnancy and risk of prematurity: a population-based cohort study.BMC medicine · 2025Article
- Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy in the LIFECODES cohort: A repeated measures study.Environmental research · 2024Article
- The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution.Scientific reports · 2023Article
- Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study.BMC medicine · 2022Article
- Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery.Journal of exposure science & environmental epidemiology · 2022Article
- Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort.Environmental health perspectives · 2022Article
- Identifying Non-Linear Association Between Maternal Free Thyroxine and Risk of Preterm Delivery by a Machine Learning Model.Frontiers in endocrinology · 2022Article
- Quantifying the Impacts of Pre- and Post-Conception TSH Levels on Birth Outcomes: An Examination of Different Machine Learning Models.Frontiers in endocrinology · 2021Article
- Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner.Frontiers in endocrinology · 2021Article
- Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort.The Science of the total environment · 2020Article
- Associations of Phthalates and Phthalate Replacements With CRH and Other Hormones Among Pregnant Women in Puerto Rico.Journal of the Endocrine Society · 2019Article
- Correction: Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth.PloS one · 2019Article
- Thyroid function in healthy and unhealthy preterm newborns.African health sciences · 2018Article
- Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study.Environment international · 2018Article
- Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth.The Journal of clinical endocrinology and metabolism · 2018Article
- Thyroid Function in Pregnant Women With Moderate to Severe Alcohol Consumption Is Related to Infant Developmental Outcomes.Frontiers in endocrinology · 2018Article
- Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study.Environment international · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
introductionOvert thyroid disease in pregnancy is associated with numerous maternal and neonatal complications including preterm birth. Less is known about the contribution of trimester-specific subclinical alterations in individual thyroid hormones, especially in late gestation, on the risk of preterm birth. Herein, we examined the associations between subclinical changes in maternal thyroid hormone concentrations (TSH, total T3, free and total T4), measured at multiple time points in pregnancy, and the odds of preterm birth in pregnant women without clinical thyroid disease. PARTICIPANTS AND
methodsData were obtained from pregnant women participating in a nested case-control study of preterm birth within on ongoing birth cohort study at Brigham and Women's Hospital in Boston, MA (N = 439; 116 cases and 323 controls). We measured thyroid hormones in plasma collected at up to four time points in pregnancy (median = 10, 18, 26, and 35 weeks). We used multivariate logistic regression models stratified by study visit of sample collection to examine associations. To reveal potential biological pathways, we also explored these relationships by obstetric presentation of preterm birth (e.g., spontaneous preterm delivery) that have been previously hypothesized to share common underlying mechanisms.
resultsIn samples collected at median 10 and 26 weeks of gestation, we found inverse associations between FT4 and the odds of overall preterm birth (odds ratio [OR] = 0.57, 95% confidence interval (CI) = 0.33, 1.00; and OR = 0.53, 95% CI = 0.34, 0.84, respectively). Positive associations were detected for total T3 at these same time points (OR = 2.52, 95% CI = 1.20, 5.31; and OR = 3.40, 95% CI = 1.56, 7.40, respectively). These effect estimates were stronger for spontaneous preterm birth.
conclusionsOur results suggest that subclinical alterations in individual maternal thyroid hormones may influence the risk of preterm birth, and the strength of these associations vary by gestational age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.