ArticlePloS one2017
Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- A quantitative treatment assessment for optimizing combined virotherapy-chemotherapy regimens against HPV-induced cervical cancer.PloS one · 2026Article
- High prevalence and atypical genotype distribution of oral human Papillomavirus in an East African HIV cohort: a cross-sectional study.BMC infectious diseases · 2025Article
- Mathematical modelling of the role of Langerhans cells in the dynamics of HPV infection.Scientific reports · 2025Article
- In-host density-dependent model of high-risk HPV virions, basal cells, lymphocytes t-cells incorporating functional responses.Heliyon · 2024Article
- HPV-Associated Anal Cancer Knowledge, Attitudes, and Health Communication Behaviors Among Non-clinical Providers at HIV/AIDS Service Organizations in Southern United States Region.Journal of cancer education : the official journal of the American Association for Cancer Education · 2022Article
- Prevalence and genotype distribution of human papillomavirus infection among HIV-infected men who have sex with men living in Lower Silesia, Poland.Postepy dermatologii i alergologii · 2022Article
- Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions.NPJ systems biology and applications · 2022Article
- Modeling and Mathematical Analysis of the Dynamics of HPV in Cervical Epithelial Cells: Transient, Acute, Latency, and Chronic Infections.Computational and mathematical methods in medicine · 2022Article
- HIV Modifies the Effect of Tobacco Smoking on Oral Human Papillomavirus Infection.The Journal of infectious diseases · 2020Article
- Human immunodeficiency virus is a driven factor of human papilloma virus among women: evidence from a cross-sectional analysis in Yaoundé, Cameroon.Virology journal · 2020Article
- Mathematical Modelling of HIV-HCV Coinfection Dynamics in Absence of Therapy.Computational and mathematical methods in medicine · 2020Article
- Human papillomavirus genotype profiles and cytological grades interlinkages in coinfection with HIV.The Pan African medical journal · 2020Article
- High-resolution computational modeling of immune responses in the gut.GigaScience · 2019Article
- Public knowledge about oral cancer in Uganda: a free dental camp experience.Journal of health research · 2019Article
- Validated Models of Immune Response to Virus Infection.Current opinion in systems biology · 2018Article
- Modulators of Redox Metabolism in Head and Neck Cancer.Antioxidants & redox signaling · 2018Review
- A Mathematical Model of Cell Cycle Dysregulation Due to Human Papillomavirus Infection.Bulletin of mathematical biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Human immunodeficiency virus (HIV)-infected patients are at an increased risk of co-infection with human papilloma virus (HPV), and subsequent malignancies such as oral cancer. To determine the role of HIV-associated immune suppression on HPV persistence and pathogenesis, and to investigate the mechanisms underlying the modulation of HPV infection and oral cancer by HIV, we developed a mathematical model of HIV/HPV co-infection. Our model captures known immunological and molecular features such as impaired HPV-specific effector T helper 1 (Th1) cell responses, and enhanced HPV infection due to HIV. We used the model to determine HPV prognosis in the presence of HIV infection, and identified conditions under which HIV infection alters HPV persistence in the oral mucosa system. The model predicts that conditions leading to HPV persistence during HIV/HPV co-infection are the permissive immune environment created by HIV and molecular interactions between the two viruses. The model also determines when HPV infection continues to persist in the short run in a co-infected patient undergoing antiretroviral therapy. Lastly, the model predicts that, under efficacious antiretroviral treatment, HPV infections will decrease in the long run due to the restoration of CD4+ T cell numbers and protective immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.