ArticleeLife2017
Perisomatic GABAergic synapses of basket cells effectively control principal neuron activity in amygdala networks.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 63 citations in OpenAlex.
- Cannabinoid modulation of central amygdala population dynamics during threat investigation.Nature communications · 2026Article
- Evolutionary neuroeconomic adaptations of fast-spiking neurons in the human neocortex.Frontiers in synaptic neuroscience · 2026Review
- Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex.The Journal of physiology · 2025Article
- Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala.Scientific reports · 2025Article
- The Role of GABA Pathway Components in Pathogenesis of Neurodevelopmental Disorders.International journal of molecular sciences · 2025Review
- Basolateral amygdala parvalbumin and cholecystokinin-expressing GABAergic neurons modulate depressive and anxiety-like behaviors.Translational psychiatry · 2024Article
- DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity.Nature methods · 2024Article
- Basolateral amygdala parvalbumin interneurons coordinate oscillations to drive reward behaviors.Current biology : CB · 2024Article
- A combinatory genetic strategy for targeting neurogliaform neurons in the mouse basolateral amygdala.Frontiers in cellular neuroscience · 2024Article
- Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety.Frontiers in cellular neuroscience · 2024Review
- Structural Organization of Perisomatic Inhibition in the Mouse Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.Communications biology · 2023Article
- Functional neuroanatomy of monoaminergic systems in the basolateral nuclear complex of the amygdala: Neuronal targets, receptors, and circuits.Journal of neuroscience research · 2023Review
- Inhibitory circuits in fear memory and fear-related disorders.Frontiers in neural circuits · 2023Review
- Fear learning and aversive stimuli differentially change excitatory synaptic transmission in perisomatic inhibitory cells of the basal amygdala.Frontiers in cellular neuroscience · 2023Article
- Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice.Nature communications · 2022Article
- Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala.Biological psychiatry · 2022Article
- Transcranial Magnetic Stimulation and Neocortical Neurons: The Micro-Macro Connection.Frontiers in neuroscience · 2022Review
- Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents.Translational psychiatry · 2021Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient control of principal neuron firing by basket cells is critical for information processing in cortical microcircuits, however, the relative contribution of their perisomatic and dendritic synapses to spike inhibition is still unknown. Using in vitro electrophysiological paired recordings we reveal that in the mouse basal amygdala cholecystokinin- and parvalbumin-containing basket cells provide equally potent control of principal neuron spiking. We performed pharmacological manipulations, light and electron microscopic investigations to show that, although basket cells innervate the entire somato-denditic membrane surface of principal neurons, the spike controlling effect is achieved primarily via the minority of synapses targeting the perisomatic region. As the innervation patterns of individual basket cells on their different postsynaptic partners show high variability, the impact of inhibitory control accomplished by single basket cells is also variable. Our results show that both basket cell types can powerfully regulate the activity in amygdala networks predominantly via their perisomatic synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.