ArticleJournal of diabetes investigation2017
Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals.
Article in Journal of diabetes investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Serum Manganese, Cobalt, Copper, Zinc, Selenium, and Iodine Levels, and the Incidence of Type 2 Diabetes: A Nested Case-control Study.Biological trace element research · 2026Article
- Article
- Serum ferritin and incident cardiometabolic diseases in Scottish adults.Cardiovascular diabetology · 2022Article
- Association of dyslipidemia, diabetes and metabolic syndrome with serum ferritin levels: a middle eastern population-based cross-sectional study.Scientific reports · 2021Article
- Hyperferritinemia Is a Predictor of Onset of Diabetes in Japanese Males Independently of Decreased Renal Function and Fatty Liver: A Fifteen-Year Follow-Up Study.Journal of clinical medicine research · 2021Article
- Serum Iron and Ferritin Levels Are Correlated with Complement C3.Biological trace element research · 2021Article
- Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity.Journal of clinical laboratory analysis · 2021Article
- Serum amino acid profiles and risk of type 2 diabetes among Japanese adults in the Hitachi Health Study.Scientific reports · 2019Article
- Serum ferritin, an early marker of cardiovascular risk: a study in Chinese men of first-degree relatives with family history of type 2 diabetes.BMC cardiovascular disorders · 2019Article
- Article
- Reference values for serum ferritin and percentage of transferrin saturation in Korean children and adolescents.Blood research · 2018Article
- Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals.Journal of diabetes investigation · 2017Article
- Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study.PloS one · 2017Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionHigher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese individuals. MATERIALS AND
methodsThe participants were 4,754 employees who attended a comprehensive health check-up in 2008-2009 and donated blood for the study. During 5 years of follow up, diabetes was identified based on plasma glucose, glycated hemoglobin and self-report. Two controls matched to each case on sex, age and date of check-up were randomly chosen using density sampling, giving 327 cases and 641 controls with ferritin measurement. Cox proportional hazards regression was used to estimate the hazard ratio while adjusting for a series of potential confounders or mediators.
resultsElevated serum ferritin levels were associated with a significantly increased risk of type 2 diabetes, with the hazard ratio adjusted for known risk factors in the highest vs lowest quartile of 1.42 (95% confidence interval: 1.03-1.96). This association was unchanged after adjustment for C-reactive protein and adiponectin, but attenuated after adjustment for liver enzyme and insulin resistance (hazard ratio 1.04). The ferritin-diabetes association was confined to non-obese participants.
conclusionsThese results suggest that elevated iron storage is associated with increased risk of type 2 diabetes in normal weight individuals, and that this association is partly mediated through liver dysfunction and resulting insulin resistance.
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