ArticleJournal of visualized experiments : JoVE2016
Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning.
Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- An open-source stereotaxic container with an integrated cutting guide for human brain fixation during magnetic resonance imaging and sectioning for histology.bioRxiv : the preprint server for biology · 2026Article
- Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography.Magnetic resonance in medicine · 2025Review
- 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions.Science (New York, N.Y.) · 2025Article
- X-ray contrast-adjustable 3D printing for multimodal fusion of microCT and histology.Frontiers in medical technology · 2025Article
- Three-dimensional histology reveals dissociable human hippocampal long-axis gradients of Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Characteristics, Prevalence, and Clinical Relevance of Juxtacortical Paramagnetic Rims in Patients With Multiple Sclerosis.Neurology · 2024Article
- Three-dimensional histology reveals dissociable human hippocampal long axis gradients of Alzheimer's pathology.bioRxiv : the preprint server for biology · 2023Article
- Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2023Article
- A 4D transcriptomic map for the evolution of multiple sclerosis-like lesions in the marmoset brain.bioRxiv : the preprint server for biology · 2023Article
- In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis.eLife · 2023Article
- Dilated Virchow-Robin Spaces are a Marker for Arterial Disease in Multiple Sclerosis.bioRxiv : the preprint server for biology · 2023Article
- Postmortem Brain Imaging in Alzheimer's Disease and Related Dementias: The South Texas Alzheimer's Disease Research Center Repository.Journal of Alzheimer's disease : JAD · 2023Article
- Transcriptomic architecture of nuclei in the marmoset CNS.Nature communications · 2022Article
- Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T.Scientific reports · 2021Article
- Ultrahigh-resolution MRI Reveals Extensive Cortical Demyelination in a Nonhuman Primate Model of Multiple Sclerosis.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Dynamic Interhemispheric Desynchronization in Marmosets and Humans With Disorders of the Corpus Callosum.Frontiers in neural circuits · 2020Article
- Potential role of iron in repair of inflammatory demyelinating lesions.The Journal of clinical investigation · 2019Article
- The "central vein sign" in inflammatory demyelination: The role of fibrillar collagen type I.Annals of neurology · 2019Article
- MR Imaging-Histology Correlation by Tailored 3D-Printed Slicer in Oncological Assessment.Contrast media & molecular imaging · 2019Review
- Internal Subdivisions of the Marmoset Claustrum Complex: Identification by Myeloarchitectural Features and High Field Strength Imaging.Frontiers in neuroanatomy · 2019Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Magnetic resonance imaging (MRI) allows for the delineation between normal and abnormal tissue on a macroscopic scale, sampling an entire tissue volume three-dimensionally. While MRI is an extremely sensitive tool for detecting tissue abnormalities, association of signal changes with an underlying pathological process is usually not straightforward. In the central nervous system, for example, inflammation, demyelination, axonal damage, gliosis, and neuronal death may all induce similar findings on MRI. As such, interpretation of MRI scans depends on the context, and radiological-histopathological correlation is therefore of the utmost importance. Unfortunately, traditional pathological sectioning of brain tissue is often imprecise and inconsistent, thus complicating the comparison between histology sections and MRI. This article presents novel methodology for accurately sectioning primate brain tissues and thus allowing precise matching between histology and MRI. The detailed protocol described in this article will assist investigators in applying this method, which relies on the creation of 3D printed brain slicers. Slightly modified, it can be easily implemented for brains of other species, including humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.