ArticleJournal of visualized experiments : JoVE2016
Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid.
Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Unravelling friction anisotropy by atomic force microscopy.Journal of microscopy · 2026Review
- Local mapping of the nanoscale viscoelastic properties of fluid membranes by AFM nanorheology.Nature communications · 2025Article
- Minimizing Structural Heterogeneity in DNA Self-Assembled Dye Templating via DNA Origami-Tuned Conformations.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Mechanical properties of human tumour tissues and their implications for cancer development.Nature reviews. Physics · 2024Article
- Quantitative Detection of Biological Nanovesicles in Drops of Saliva Using Microcantilevers.ACS applied materials & interfaces · 2024Article
- Interaction of βInternational journal of molecular sciences · 2023Article
- Review
- Data acquisition and imaging using wavelet transform: a new path for high speed transient force microscopy.Nanoscale advances · 2021Article
- Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19.ACS nano · 2020Review
- Effect of Ageing on the Structure and Properties of Model Liquid-Infused Surfaces.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Lubricated friction around nanodefects.Science advances · 2020Article
- Direct Measurement of Plant Cellulose Microfibril and Bundles in Native Cell Walls.Frontiers in plant science · 2020Article
- Subcellular Imaging of Liquid Silicone Coated-Intestinal Epithelial Cells.Scientific reports · 2018Article
- Isothermal folding of a light-up bio-orthogonal RNA origami nanoribbon.Scientific reports · 2018Article
- Ions Modulate Stress-Induced Nanotexture in Supported Fluid Lipid Bilayers.Biophysical journal · 2017Article
- Direct observation of the dynamics of single metal ions at the interface with solids in aqueous solutions.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Atomic force microscopy (AFM) has become a well-established technique for nanoscale imaging of samples in air and in liquid. Recent studies have shown that when operated in amplitude-modulation (tapping) mode, atomic or molecular-level resolution images can be achieved over a wide range of soft and hard samples in liquid. In these situations, small oscillation amplitudes (SAM-AFM) enhance the resolution by exploiting the solvated liquid at the surface of the sample. Although the technique has been successfully applied across fields as diverse as materials science, biology and biophysics and surface chemistry, obtaining high-resolution images in liquid can still remain challenging for novice users. This is partly due to the large number of variables to control and optimize such as the choice of cantilever, the sample preparation, and the correct manipulation of the imaging parameters. Here, we present a protocol for achieving high-resolution images of hard and soft samples in fluid using SAM-AFM on a commercial instrument. Our goal is to provide a step-by-step practical guide to achieving high-resolution images, including the cleaning and preparation of the apparatus and the sample, the choice of cantilever and optimization of the imaging parameters. For each step, we explain the scientific rationale behind our choices to facilitate the adaptation of the methodology to every user's specific system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.