Evidence map›Paper›PMID 28060225›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2017

Brief Report: Association Between Menopause and Unprotected Sex in High-Risk HIV-Positive Women in Mombasa, Kenya.

Marielle S Goyette, Kate S Wilson, Ruth Deya, Linnet N Masese, Juma Shafi, Barbra A Richardson, Kishorchandra Mandaliya, Walter Jaoko, R Scott McClelland

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Marielle S Goyette*Department of Epidemiology, University of Washington, Seattle, WA; †Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya; ‡Department of Medicine, University of Washington, Seattle, WA; Departments of §Global Health; and ∥Biostatistics, University of Washington, Seattle, WA.
Kate S Wilson
Ruth Deya
Linnet N Masese
Juma Shafi
Barbra A Richardson
Kishorchandra Mandaliya
Walter Jaoko
R Scott McClelland
University of Nairobi · KEUniversity of Washington · USCenter for Global Health · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Women's Life Events & HIV Transmission Potential: A Multidisciplinary StudyR01HD072617 · NICHD · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2012 to 2016
$2.1M
NIAID NIH HHS P30 AI027757NICHD NIH HHS R01 HD072617
6 · The paper itself

Abstract

objectiveMany HIV-positive women now live well beyond menopause. Postmenopausal women are no longer at risk for pregnancy, and some studies suggest that they may use condoms less often than premenopausal women. This study tests the hypothesis that, in HIV-positive women who report trading sex for cash or in-kind payment, unprotected sex is more common at postmenopausal visits compared with premenopausal visits.

designProspective cohort study of HIV-positive women ≥16 years old in Mombasa, Kenya.

methodsAt enrollment and monthly follow-up visits, participants completed a standardized interview. Study clinicians collected genital samples at enrollment and quarterly visits. Menopausal status was assessed annually. The primary outcome of unprotected sex was determined by detection of prostate specific antigen (PSA) in vaginal secretions.

resultsThis study followed 404 HIV-positive women who contributed 2753 quarterly examination visits. Detection of PSA was less frequent at postmenopausal visits compared with premenopausal visits [55/554, 10.5% versus 394/2199, 17.9%; relative risk (RR) 0.58, 95% confidence interval (CI): 0.39 to 0.87]. Adjusting for age diminished the association between menopause and PSA detection (adjusted RR 0.73, 95% CI: 0.47 to 1.14). At visits where women reported sexual activity in the past week, they reported similar rates of 100% condom use at postmenopausal and premenopausal visits (RR 0.99, 95% CI: 0.87 to 1.13).

conclusionsIn this population of high-risk HIV-positive Kenyan women, postmenopausal status was not associated with a greater risk of unprotected sex. The relationship between menopause and unprotected sex is likely context specific and may differ with varying risk groups, regions, and levels of exposure to sexual health education.

Indexed as

MenopauseRisk-TakingSex WorkersUnsafe SexAdultFemaleFollow-Up StudiesHIV InfectionsHumansInterviews as TopicKenyaMiddle AgedProspective Studies

Identifiers

PMID28060225
PMCPMC5340629
OpenAlexW2569400540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.