Evidence map›Paper›PMID 28060130›Full record

ArticleJournal of pediatric hematology/oncology2017

Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma.

Michael V Ortiz, Heather Magnan, Emily K Slotkin, Srikanth R Ambati, Alexander J Chou, Leonard H Wexler, Paul A Meyers, Michael F Walsh, Todd Heaton, Leonard N Girardi and 8 more

Abstract readCase Reports
In one paragraph

Article in Journal of pediatric hematology/oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Michael V OrtizDepartments of *Pediatrics †Medicine ‡Surgery ∥Radiation Oncology ¶Radiology #Pathology **Human Oncology and Pathogenesis Program, Molecular Pharmacology Program ††Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center §Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.
Heather Magnan
Emily K Slotkin
Srikanth R Ambati
Alexander J Chou
Leonard H Wexler
Paul A Meyers
Michael F Walsh
Todd Heaton
Leonard N Girardi
Suzanne L Wolden
Anita P Price
Jennifer A Kennedy
Ahmet Zehir
Meera Hameed
Michael F Berger
Alex Kentsis
Neerav Shukla
Pediatrics and Genetics · USMemorial Sloan Kettering Cancer Center · USRadiation Oncology Associates · USWeill Cornell Medicine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MSK Paul Calabresi Career Development Award for Clinical OncologyK12CA184746 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Omar Abdel-Wahab, Simon N. Powell · 2015 to 2026
$8.3M
Structure and function of genome plasticity in human cancerR01CA214812 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KENTSIS, ALEX · 2018 to 2022
$2.5M
NCI NIH HHS K12 CA184746NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA214812
6 · The paper itself

Abstract

A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.

Indexed as

Neoplasms, Second PrimaryAdolescentAntineoplastic Combined Chemotherapy ProtocolsBiopsyCalmodulin-Binding ProteinsHeart NeoplasmsHumansMaleMutationRNA-Binding Protein EWSRNA-Binding ProteinsSarcomaSarcoma, EwingTomography, X-Ray ComputedCalmodulin-Binding ProteinsEWSR1 protein, humanRNA-Binding Protein EWSRNA-Binding Proteins

Identifiers

PMID28060130
PMCPMC5498269
OpenAlexW2571220544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.