ArticleThe Pediatric infectious disease journal2017
Epidemiology and Molecular Characteristics of Mycoplasma pneumoniae During an Outbreak of M. pneumoniae-associated Stevens-Johnson Syndrome.
Article in The Pediatric infectious disease journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Review
- The Post-Pandemic Return ofJournal of clinical medicine · 2026Article
- Epidemiological characteristics of community-acquiredTranslational pediatrics · 2024Article
- Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia.American journal of translational research · 2024Article
- Bronchiolitis obliterans associated with toxic epidermal necrolysis induced by infection: A case report and literature review.Frontiers in pediatrics · 2023Article
- Article
- Molecular Tools for TypingFrontiers in microbiology · 2022Review
- Case Report and Literature Review: Clinical Characteristics of 10 Children WithFrontiers in pediatrics · 2022Article
- Mycoplasma pneumoniae Genotypes and Clinical Outcome in Children.Journal of clinical microbiology · 2021Article
- Effect of COVID-19 on childhood Mycoplasma pneumoniae infection in Chengdu, China.BMC pediatrics · 2021Article
- An unusual cause of Steven-Johnson Syndrome.Acta bio-medica : Atenei Parmensis · 2020Article
- Mycoplasma pneumoniae Among Children Hospitalized With Community-acquired Pneumonia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.Journal of immunology research · 2018Article
- Article
- SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.The journal of allergy and clinical immunology. In practiceReview
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Authors and funding
13 authors.
Funding
Abstract
backgroundAn increase in Mycoplasma pneumoniae-associated Stevens-Johnson syndrome (SJS) cases at a Colorado pediatric hospital led to an outbreak investigation. We describe the epidemiologic and molecular characteristics of M. pneumoniae among SJS case-patients and surrounding community members during the outbreak.
methodsM. pneumoniae polymerase chain reaction-positive respiratory specimens from 5 Colorado hospitals and 4 referral laboratories underwent confirmatory polymerase chain reaction testing; positive specimens then underwent multilocus variable-number tandem-repeat analysis (MLVA) and macrolide resistance testing. Three SJS-M. pneumoniae case-patient households were surveyed using a standardized questionnaire, and nasopharyngeal/oropharyngeal swabs were obtained from all consenting/assenting household contacts. International Classification of Diseases, 9th revision codes were used to identify pneumonia cases among Colorado patients 5-21 years of age from January 2009 to March 2014.
resultsThree different M. pneumoniae MLVA types were identified among the 5 SJS case-patients with confirmed infection; MLVA type 3-X-6-2 was seen more commonly in SJS case-patients (60%) than in 69 non-SJS community specimens (29%). Macrolide resistance was identified in 7% of community specimens but not among SJS case-patients. Of 15 household contacts, 5 (33%) were M. pneumoniae positive; all MLVA types were identical to those of the corresponding SJS case-patient, although the specimen from 1 contact was macrolide resistant. Overall pneumonia cases as well as those caused by M. pneumoniae specifically peaked in October 2013, coinciding with the SJS outbreak.
conclusionsThe outbreak of M. pneumoniae-associated SJS may have been associated with a community outbreak of M. pneumoniae; clinicians should be aware of the M. pneumoniae-SJS relationship. Household transmission of M. pneumoniae was common within the households investigated.
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