Evidence map›Paper›PMID 28059802›Full record

ReviewRestorative neurology and neuroscience2017

Recent progress in translational research on neurovascular and neurodegenerative disorders.

Hans-Ulrich Demuth, Rick M Dijkhuizen, Tracy D Farr, Mathias Gelderblom, Karen Horsburgh, Costantino Iadecola, Damian D Mcleod, Dominik Michalski, Tim H Murphy, Josune Orbe and 17 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Restorative neurology and neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Ageing, Neurodegeneration and the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Action Plan for Stroke in Europe 2018-2030.European stroke journal · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 8 countries.

Hans-Ulrich DemuthDepartment of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology (IZI-MWT), Halle/Saale, Germany.
Rick M DijkhuizenBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, The Netherlands.
Tracy D FarrSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Mathias GelderblomDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Karen HorsburghCentre for Neuroregeneration, University of Edinburgh, Edinburgh, UK.
Costantino IadecolaBrain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Damian D McleodUniversity of Newcastle, Hunter Medical Research Institute and Hunter New England Local Health District, Newcastle, Australia.
Dominik MichalskiDepartment of Neurology, University of Leipzig, Leipzig, Germany.
Tim H MurphyDepartment of Psychiatry, University of British Columbia, Vancouver, Canada.
Josune OrbeAtherothrombosis Laboratory, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.
Willem M OtteBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, The Netherlands.
Gabor C PetzoldGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Nikolaus PlesnilaInstitute for Stroke and Dementia Research (ISD), University of Munich Medical Center; Munich Cluster of Systems Neurology (Synergy), LMU Munich, Germany.
Georg ReiserInstitute for Neurobiochemistry, University of Magdeburg, Magdeburg, Germany.
Klaus G ReymannNeuropharmacology Lab, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Maria A RuegerDepartment of Neurology, University Hospital of Cologne, Cologne, Germany.
Dorothee SaurDepartment of Neurology, University of Leipzig, Leipzig, Germany.
Sean I SavitzDepartment of Neurology, UTHealth Medical School, Houston, TX, USA.
Stephan SchillingDepartment of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology (IZI-MWT), Halle/Saale, Germany.
Neil J SprattUniversity of Newcastle, Hunter Medical Research Institute and Hunter New England Local Health District, Newcastle, Australia.
Renée J TurnerAdelaide Medical School and Adelaide Centre for Neuroscience Research, The University of Adelaide, Adelaide, Australia.
Raghu VemugantiDeptartment of Neurological Surgery, University of Wisconsin and William S. Middleton VA Hospital, Madison, WI, USA.
Denis VivienCell Biology and Clinical Research Department, Medical Center, Université Caen-Normandie, GIP Cyceron; Inserm, Inserm UMR-S U919, Serine Proteases and Pathophysiology of the neurovascular Unit, Caen, France.
Manuel YepesDepartment of Neurology, Emory University, Atlanta, GA, USA.
Marietta ZilleDepartment of Neurology and Neuroscience, The Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, NY, USA.
Johannes BoltzeDepartment of Medical Cell Technology, Fraunhofer Research Institution for Marine Biotechnology; Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany.
ISN&N meeting contributors
Hunter Medical Research Institute · AUFraunhofer Institute for Cell Therapy and Immunology · DECornell University · USLeipzig University · DEUniversity Medical Center Utrecht · NLEmory University · USGerman Center for Neurodegenerative Diseases · DEGTx (United States) · USInserm · FRLeibniz Institute for Neurobiology · DEMunich Cluster for Systems Neurology · DEThe University of Adelaide · AUThe University of Texas Health Science Center at Houston · USUniversidad de Navarra · ESUniversität Hamburg · DEUniversity Hospital Cologne · DEUniversity Hospital Magdeburg · DEUniversity of British Columbia · CAUniversity of Edinburgh · GBUniversity of Nottingham · GB

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Overexpression of the amyloid precursor protein and cerebrovascular regulationR01NS037853 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Costantino Iadecola · 1998 to 2026
$10.6M
Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular RiskR01NS095441 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2025
$4.7M
ApoE4 and mechanisms of diffuse white matter injuryR01NS100447 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2020
$3.5M
Hypertension and neurovascular dysfunctionR37NS089323 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2015 to 2021
$3.1M
Stress Proteins in Brain Cell InjuryR01NS084396 · NINDS · STANFORD UNIVERSITY · PI GIFFARD, RONA G · 2013 to 2017
$1.7M
Medical Research Council MR/K026992/1NIH HHS P51 OD011132NINDS NIH HHS R01 NS037853NINDS NIH HHS R01 NS084396NINDS NIH HHS R01 NS095441NINDS NIH HHS R01 NS100447NINDS NIH HHS R37 NS089323
6 · The paper itself

Abstract

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient's outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.

Indexed as

Translational Research, BiomedicalAnimalsCerebrovascular DisordersHumansNeurodegenerative DiseasesAlzheimer’s diseasebraincerebral ischemiacerebral small vessel diseasedementiaexperimental therapyhemorrhagein vivo imagingneuroimmunologyneuroprotectionneurorepairsex differencesstroketranslational researchvascular cognitive impairment

Identifiers

PMID28059802
PMCPMC5302043
OpenAlexW2567382930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.