ArticleScience (New York, N.Y.)2017
Regeneration of fat cells from myofibroblasts during wound healing.
Open access · bronzeAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
348citing papers in PubMed, 1 pooled it
33.1field-weighted citation impact, top 1% of its field
What it found
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Who cites it
348 citing papers in PubMed, 1 synthesis or guideline pooled it, 565 citations in OpenAlex.
- Fibroblasts in Scar Formation: Biology and Clinical Translation.Oxidative medicine and cellular longevity · 2022Pooled it
- A multifunctional DECM/PLMA hydrogel incorporated with engineered PRP-derived exosomes enabling PHD2 silencing for skin wound repair.Bioactive materials · 2027Article
- A regenerative fibroblast competence field supports multiple cell fates in adult skin regeneration.bioRxiv : the preprint server for biology · 2026Article
- BMP4 cocktail promotes utricular progenitor reprogramming and vestibular functional recovery in adult mice.Journal of advanced research · 2026Article
- Article
- Pulmonary fibroblast subsets demonstrate differentially enriched signaling pathways during fibrosis resolution and repair.JCI insight · 2026Article
- Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs.JCI insight · 2026Review
- Reprogramming in delipidated adipocytes: metabolism, regulation and progress.Cell death discovery · 2026Review
- PDGF signaling regulates the adipocyte-to-fibroblast transition in wound healing.Cell reports · 2026Article
- Exploring mechanisms of scar-free skin wound healing in adult zebrafish in comparison to mouse.PLoS genetics · 2026Article
- Fibroblasts as regulators of lung immunity, repair and fibrosis.Nature reviews. Immunology · 2026Review
- Article
- Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling.Cell reports. Medicine · 2026Article
- RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies.Life (Basel, Switzerland) · 2026Review
- A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin.Experimental & molecular medicine · 2026Article
- Cancer-associated fibroblasts as key regulators of lipid metabolism in the tumour microenvironment.Oncogene · 2026Review
- Engineered polypeptide cascade-release platform restores macrophage plasticity for accelerated diabetic wound healing.Bioactive materials · 2026Article
- Microalgae as a Novel Therapy for Chronic Wound Healing.International wound journal · 2026Review
- Adipocytes as core drivers of skin aging and novel targets for regeneration.Biogerontology · 2026Review
- Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances.Exploration (Beijing, China) · 2026Review
288 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
38 authors at 11 institutions in 4 countries.
Maksim V PlikusDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. plikus@uci.edu cotsarel@mail.med.upenn.edu.ORCID 0000-0002-8845-2559
Christian F Guerrero-JuarezDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-6245-6412
Mayumi ItoThe Ronald O. Perelman Department of Dermatology, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
Yun Rose LiThe Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8077-4975
Priya H DedhiaDepartment of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ying ZhengDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1906-9660
Mengle ShaoTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5488-9904
Denise L GayDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7340-8427
Raul RamosDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Tsai-Ching HsiDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Ji Won OhDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-5742-5120
Xiaojie WangDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Amanda RamirezDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-9584-7674
Sara E KonopelskiDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Arijh ElzeinDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-6122-6220
Anne WangDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7064-7895
Rarinthip June SupapannachartDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Hye-Lim LeeDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Chae Ho LimThe Ronald O. Perelman Department of Dermatology, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
Arben NaceDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1039-4042
Amy GuoDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-6298-4821
Elsa TreffeisenDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Thomas AndlBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 328116, USA.
Ricardo N RamirezDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-1259-5406
Rabi MuradDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Stefan OffermannsDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.
Daniel MetzgerInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, INSERM U964, Université de Strasbourg, Illkirch 67404, France.ORCID 0000-0002-5555-046X
Pierre ChambonInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, INSERM U964, Institut d'Etudes Avancées de l'Université de Strasbourg, Collège de France, Illkirch 67404, France.
Alan D WidgerowCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, Irvine, CA 92868, USA.ORCID 0000-0002-5705-8073
Tai-Lan TuanThe Saban Research Institute of Children's Hospital Los Angeles and Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0000-0002-7746-4677
Ali MortazaviDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Rana K GuptaTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Bruce A HamiltonDepartments of Medicine and Cellular and Molecular Medicine, Moores Cancer Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Sarah E MillarDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Patrick SealeThe Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Warren S PearDepartment of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2624-0526
Mitchell A LazarThe Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8653-1280
George CotsarelisDepartment of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. plikus@uci.edu cotsarel@mail.med.upenn.edu.ORCID 0000-0003-3534-9408
University of California, Irvine · USUniversity of Pennsylvania · USCancer Research Institute · USCentre National de la Recherche Scientifique · FRNew York University · USThe University of Texas Southwestern Medical Center · USChildren's Hospital of Los Angeles · USInserm · FRLa Jolla Institute For Molecular Medicine · USMax Planck Institute for Heart and Lung Research · DEUniversity of Central Florida · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3MZINC FINGER PROTEINS IN EARLY KIDNEY DEVELOPMENTP01DK049210 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI AHIMA, REXFORD S. · 1995 to 2016
$26.9MMINORITY BIOMEDICAL RESEARCHERS PROGRAMR25GM055246 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOTA-BRAVO, LUIS M · 1996 to 2022
$15.3MNuclear Receptors in Metabolic TissuesR01DK049780 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LAZAR, MITCHELL A. · 1995 to 2025
$10.8MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MStudy Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6MNotch Regulation of Hematopoietic Cell FatesR01AI047833 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI JORDAN, MARTHA S, PEAR, WARREN S · 2000 to 2022
$7.4MThe regulation of melanocyte stem cells by Wnt signalingR01AR059768 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ITO, MAYUMI · 2011 to 2025
$6.9MEstablishment and Maintenance of Healthy Adipose Tissue in ObesityR01DK104789 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2015 to 2024
$3.9MWNT signals in skin and hair development and hair growthR37AR047709 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MILLAR, SARAH E. · 2012 to 2021
$3.6MHair Follicle Neogenesis in Response to WoundingR01AR055309 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI COTSARELIS, GEORGE · 2007 to 2017
$3.5MUnderstanding molecular mechanisms underlying the formation of the blue nevus andP30AR057217 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI STANLEY, JOHN R · 2009 to 2013
$3.2MNCI NIH HHS T32 CA009054NIAID NIH HHS R01 AI047833NIAMS NIH HHS P30 AR057217NIAMS NIH HHS P30 AR069589NIAMS NIH HHS R01 AR055309NIAMS NIH HHS R01 AR059768NIAMS NIH HHS R01 AR066022NIAMS NIH HHS R01 AR067273NIAMS NIH HHS R01 AR069653NIAMS NIH HHS R37 AR047709NIAMS NIH HHS T32 AR064184NIDDK NIH HHS P01 DK049210NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK049780NIDDK NIH HHS R01 DK103008NIDDK NIH HHS R01 DK104789NIGMS NIH HHS DP2 GM111100NIGMS NIH HHS R01 GM095821NIGMS NIH HHS R25 GM055246
Abstract
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro
Indexed as
Cellular ReprogrammingRegenerationWound HealingAdipocytesAnimalsBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic ProteinsCells, CulturedCicatrixDNA-Binding ProteinsFibroblastsHair FollicleHumansMiceMice, Inbred C57BLBMP2 protein, humanBMP4 protein, humanBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic ProteinsDNA-Binding ProteinsEbfaz protein, mouseRecombinant ProteinsTranscription Factors
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