Evidence map›Paper›PMID 28059709›Full record

ArticleAJNR. American journal of neuroradiology2017

Microstructure of the Default Mode Network in Preterm Infants.

J Cui, O Tymofiyeva, R Desikan, T Flynn, H Kim, D Gano, C P Hess, D M Ferriero, A J Barkovich, D Xu

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

J CuiFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.).ORCID 0000-0003-2492-5887
O TymofiyevaFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.).ORCID 0000-0003-2589-1041
R DesikanFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.).ORCID 0000-0002-4151-6017
T FlynnFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.).ORCID 0000-0001-5532-4027
H KimFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.).ORCID 0000-0002-2269-8644
D GanoPediatrics and Neurology (D.G., D.M.F.), University of California, San Francisco, San Francisco, California.ORCID 0000-0003-4192-2362
C P HessFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.).ORCID 0000-0002-5132-5302
D M FerrieroPediatrics and Neurology (D.G., D.M.F.), University of California, San Francisco, San Francisco, California.ORCID 0000-0003-0560-9045
A J BarkovichFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.).ORCID 0000-0003-4291-7346
D XuFrom the Departments of Radiology and Biomedical Imaging (J.C., O.T., R.D., T.F., H.K., C.P.H., A.J.B., D.X.) Duan.Xu@ucsf.edu.ORCID 0000-0003-0550-4235
Laboratoire d’Imagerie Biomédicale · FRUniversity of California, San Francisco · US

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1M
Repair in High Risk Newborns with Congential Heart DiseaseP01NS082330 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XU, DUAN · 2014 to 2018
$6.0M
Development of Advanced Techniques for MR of the Newborn BrainR01EB009756 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARKOVICH, ANTHONY JAMES, XU, DUAN · 2009 to 2013
$5.5M
MRI, MRSI, AND DTI OF BRAIN INJURY IN PRETERM NEONATESR01NS046432 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARKOVICH, ANTHONY JAMES · 2004 to 2013
$4.3M
Towards Baby Brain Connectome: a Study of Newborn Brain NetworksR01HD072074 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HESS, CHRISTOPHER PAUL, XU, DUAN · 2013 to 2017
$3.0M
A Network Approach to Study Brain Plasticity in Children with Cognitive TrainingR21AT009173 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TYMOFIYEVA, OLGA · 2016 to 2017
$436k
NCCIH NIH HHS R21 AT009173NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB009756NICHD NIH HHS R01 HD072074NINDS NIH HHS P01 NS082330NINDS NIH HHS R01 NS046432
6 · The paper itself

Abstract

background and purposeDiffusion and fMRI has been providing insights to brain development in addition to anatomic imaging. This study aimed to evaluate the microstructure of white matter tracts underlying the default mode network in premature infants by using resting-state functional MR imaging in conjunction with diffusion tensor imaging-based tractography. MATERIALS AND

methodsA cohort of 44 preterm infants underwent structural T1-weighted imaging, resting-state fMRI, and DTI at 3T, including 21 infants with brain injuries and 23 infants with normal-appearing structural imaging as controls. Neurodevelopment was evaluated with the Bayley Scales of Infant Development at 12 months' adjusted age. Probabilistic independent component analysis was applied to resting-state fMRI data to explore resting-state networks. The localized clusters of the default mode network were used as seeding for probabilistic tractography. The DTI metrics (fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity) of the reconstructed primary tracts within the default mode network-cingula were measured.

resultsResults revealed decreased fractional anisotropy (0.20 ± 0.03) and elevated radial diffusivity values (1.24 ± 0.16) of the cingula in the preterm infants with brain injuries compared with controls (fractional anisotropy, 0.25 ± 0.03;

conclusionsThis study of combined resting-state fMRI and DTI at rest suggests that such studies may allow the investigation of key functional brain circuits in premature infants, which could function not only as diagnostic tools but also as biomarkers for long-term neurodevelopmental outcomes.

Indexed as

AnisotropyBrainBrain MappingDiffusion Tensor ImagingFemaleHumansInfantInfant, NewbornInfant, PrematureMagnetic Resonance ImagingMaleWhite Matter

Identifiers

PMID28059709
PMCPMC5309151
OpenAlexW2554534405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.