Evidence map›Paper›PMID 28059670›Full record

ArticleHuman vaccines & immunotherapeutics2017

Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients.

Pryscilla Fanini Wowk, Luís Henrique Franco, Denise Morais da Fonseca, Marina Oliveira Paula, Élcio Dos Santos Oliveira Vianna, Ana Paula Wendling, Valéria Maria Augusto, Silvana Maria Elói-Santos, Andréa Teixeira-Carvalho, Flávia Dias Coelho Silva and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Pryscilla Fanini Wowka Department of Biochemistry and Immunology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil.
Luís Henrique Francoa Department of Biochemistry and Immunology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil.
Denise Morais da Fonsecaa Department of Biochemistry and Immunology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil.
Marina Oliveira Paulaa Department of Biochemistry and Immunology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil.
Élcio Dos Santos Oliveira Viannab Respiratory Division, School of Medicine of Ribeirão Preto, University of São Paulo , São Paulo , Ribeirão Preto , Brazil.
Ana Paula Wendlingc Laboratory of Biomarkers for Diagnosis and Monitoring , René Rachou Research Center , Fiocruz, Belo Horizonte , Minas Gerais , Brazil.
Valéria Maria Augustod Federal University of Minas Gerais , Belo Horizonte , Brazil.
Silvana Maria Elói-Santosd Federal University of Minas Gerais , Belo Horizonte , Brazil.
Andréa Teixeira-Carvalhoc Laboratory of Biomarkers for Diagnosis and Monitoring , René Rachou Research Center , Fiocruz, Belo Horizonte , Minas Gerais , Brazil.
Flávia Dias Coelho Silvae Mycobacteriology Laboratory, Nucleus of Infectious Diseases , Federal University of Espírito Santo , Vitória , Espírito Santos , Brazil.
Solange Alves Vinhase Mycobacteriology Laboratory, Nucleus of Infectious Diseases , Federal University of Espírito Santo , Vitória , Espírito Santos , Brazil.
Olindo Assis Martins-Filhoc Laboratory of Biomarkers for Diagnosis and Monitoring , René Rachou Research Center , Fiocruz, Belo Horizonte , Minas Gerais , Brazil.
Moisés Palacie Mycobacteriology Laboratory, Nucleus of Infectious Diseases , Federal University of Espírito Santo , Vitória , Espírito Santos , Brazil.
Célio Lopes Silvaa Department of Biochemistry and Immunology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil.
Vânia Luiza Deperon Bonatoa Department of Biochemistry and Immunology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil.
Universidade de São Paulo · BRUniversidade Federal do Espírito Santo · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously we showed that 65-kDa Mycobacterium leprae heat shock protein (Hsp65) is a target for the development of a tuberculosis vaccine. Here we evaluated peripheral blood mononuclear cells (PBMC) from healthy individuals or tuberculosis patients stimulated with two forms of Hsp65 antigen, recombinant DNA that encodes Hsp65 (DNA-HSP65) or recombinant Hsp65 protein (rHsp65) in attempting to mimic a prophylactic or therapeutic study in vitro, respectively. Proliferation and cytokine-producing CD4

Indexed as

Immunity, CellularLymphocyte ActivationAdultBacterial ProteinsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChaperonin 60Cytotoxicity, ImmunologicFemaleHealthy VolunteersHumansInterferon-gammaInterleukin-10Leukocytes, MononuclearMacrophages, AlveolarMaleBacterial ProteinsChaperonin 60heat-shock protein 65, MycobacteriumInterferon-gammaInterleukin-10Recombinant ProteinsTuberculosis VaccinesVaccines, DNAIFN-γIL-10tuberculosisvaccine

Identifiers

PMID28059670
PMCPMC5443371
OpenAlexW2568402710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.