ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2017
Smokers with MS have greater decrements in quality of life and disability than non-smokers.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Preventive strategies in neuroimmunology.Neurological research and practice · 2026Review
- Self-regulation resource model of body compassion in multiple sclerosis.Rehabilitation psychology · 2026Article
- Impact of tobacco and alcohol consumption on disease progression and MRI in people with multiple sclerosis: results of the prospective cohort study NationMS.Therapeutic advances in neurological disorders · 2026Article
- Article
- Smoking status and vascular risk factors as predictors of disability in AQP4-NMOSD and MOGAD.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Smoking and multiple sclerosis: development and feasibility study of a MS-specific smoking cessation intervention.Therapeutic advances in neurological disorders · 2025Article
- Motivators and barriers for smoking cessation in people with multiple sclerosis: a qualitative study to inform the design of a tailored intervention.BMC public health · 2024Article
- Investigating disparities in smoking cessation treatment for veterans with multiple sclerosis: A national analysis.Brain and behavior · 2024Article
- The effect of smoking on MRI lesion resolution in NMOSD-AQP4 and MOGAD.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Cellular and Molecular Evidence of Multiple Sclerosis Diagnosis and Treatment Challenges.Journal of clinical medicine · 2023Review
- Health behaviors of people with multiple sclerosis and its associations with MS related outcomes: a German clinical cohort.Frontiers in neurology · 2023Article
- Associations between smoking and walking, fatigue, depression, and health-related quality of life in persons with multiple sclerosis.Acta neurologica Belgica · 2021Article
- Predicting onset of secondary-progressive multiple sclerosis using genetic and non-genetic factors.Journal of neurology · 2020Article
- Modifiable risk factors for poor health outcomes in multiple sclerosis: The urgent need for research to maximise smoking cessation success.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Review
- Beyond rehabilitation: A prevention model of reserve and brain maintenance in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Review
- Association of cigarette smoking with neuromyelitis optica-immunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder.Iranian journal of neurology · 2019Article
- The Role of Diet in Multiple Sclerosis: Mechanistic Connections and Current Evidence.Current nutrition reports · 2018Review
- Longitudinal Associations of the Healthy Lifestyle Index Score With Quality of Life in People With Multiple Sclerosis: A Prospective Cohort Study.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTobacco smoke plays a pathogenic role in multiple sclerosis (MS) and may accelerate disease progression, yet, some people with MS continue to smoke after disease onset. The average smoker reports diminished health-related quality of life (HRQOL) across many populations.
objectivesTo describe the relationships between smoking status and HRQOL, disease activity, and global disability in a US population with MS.
methodsWe compared smokers to non-smokers in 950 responders to the Spring 2014 update survey completed by North American Research Committee on Multiple Sclerosis (NARCOMS) registry participants. HRQOL was assessed using Short Form-12 version 2 (SF-12v2), disease activity was investigated using eight Performance Scales (PS) and three Functionality Scales (FS). Global disability was evaluated using Patient Determined Disease Steps (PDDS) and an item response theory (IRT) summed score based on the PS and FS.
resultsSmokers had lower HRQOL ( p < 0.0001), reported more disease activity ( p < 0.05) and greater deficits in all PS and FS ( p = 6 × 10
conclusionActive smoking is meaningfully associated with deficits across multiple domains in people with MS and adds to the growing literature of the need for MS-tailored smoking cessation programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.